Kp predictor
Kp prediction based on Rodgers, et al. Research only.
Inputs
System properties
Species
Mouse (Body weight: 0.025 kg)
Rat (Body weight: 0.25 kg)
Rhesus Monkey (Body weight: 5 kg)
Human male (Body weight: 65 kg)
Compound properties
Physicochemical properties
Compound type
Monoprotic acid
Monoprotic base
Diprotic acid
Diprotic base
Zwitterion
Neutral
pKa
pKa
1
pKa
2
pKa
acid
pKa
base
logD
pH7.4
logP
o:w
(Octanol:Water)
logP
vo:w
(Olive oil:Water)
Predict logP
vo:w
(Hansch equation)
Hansch equation:
Blood partitioning properties
f
up
(Free fraction in plasma)
R (Blood-to-plasma partition coefficient)
Calculate
Results
K
p
Wait a moment...