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Min-Soo Kim's blog

Education

  • 2016.03 ~ 2022.08
    • Ph.D. in Pharmacy (Pharmaceutics)
      College of Pharmacy, Seoul National University, Seoul, Korea.
      Dissertation: “Physiologically-based pharmacokinetic modeling for the prediction of the pharmacological effect of fexuprazan and the extent of atorvastatin-fimasartan interaction in humans”
      Supervisor: Prof. Suk-Jae Chung, Ph.D.

  • 2012.03 ~ 2016.02
    • Pharm D.
      College of Pharmacy, Korea University, Sejong, Korea.
  • 2009.03 ~ 2012.02
    • Pre-pharmacy, Environmental science & ecological engineering
      College of Life Science & Biotechnology, Korea University, Seoul, Korea.

Publications

  1. S Lee, M-S Kim, J-W Jeong, J Chae, T-S Koo, H-J Maeng, S-J Chung, K-R Lee, Y-J Chae. Bioanalysis of alpelisib using liquid chromatography–tandem mass spectrometry and application to pharmacokinetic study. Journal of Analytical Science and Technology. 2022; DOI: 10.1186/s40543-022-00340-7.
  2. Y-S Jeong, M-S Kim, S-J Chung, Determination of the Number of Tissue Groups of Kinetically Distinct Transit Time in Whole-Body Physiologically-Based Pharmacokinetic (PBPK) Models I: Theoretical Consideration of Bottom-up Approach of Lumping Tissues in Whole-Body PBPK. AAPS Journal. 2022.
  3. Y-S Jeong, M-S Kim, S-J Chung, Determination of the Number of Tissue Groups of Kinetically Distinct Transit Time in Whole-Body Physiologically-Based Pharmacokinetic (PBPK) Models II: Practical Application of Tissue Lumping Theories for Pharmacokinetics of Various Compounds. AAPS Journal. 2022.
  4. Y-K Song, M-J Kim, M-S Kim, J Lee, S-J Chung, J Song, Y-J Chae, K-R Lee, Role of the efflux transporters Abcb1 and Abcg2 in the brain distribution of olaparib in mice. European Journal of Pharmaceutical Sciences. 2022; 173.
  5. M-S Kim, N Lee, A Lee, Y-J Chae, S-J Chung, and K-R Lee. Model-Based Prediction of Acid Suppression and Proposal of a New Dosing Regimen of Fexuprazan in Humans. Pharmaceuticals. 2022; 15(6):709.
  6. M Lee, Y-S Jeong, M-S Kim, K-M An, and S-J Chung. Prediction of Pharmacokinetics of IDP-73152 in Humans Using Physiologically-Based Pharmacokinetics. Pharmaceutics. 2022; 14(6):1157.
  7. Y-S Jeong, M-S Kim, N Lee, Y-J Chae, S-J Chung, and K-R Lee. Development of Physiologically Based Pharmacokinetic Model for Orally Administered Fexuprazan in Humans. Pharmaceutics. 2021;13(6):813.
  8. Y-J Chae, M-S Kim, S-J Chung, M-K Lee, K-R Lee, and H-J Maeng. Pharmacokinetic Estimation Models-based Approach to Predict Clinical Implications for CYP Induction by Calcitriol in Human Cryopreserved Hepatocytes and HepaRG Cells. Pharmaceutics. 2021;13(2):181.
  9. Y-S Jeong, M Baek, S Lee, M-S Kim, H-J Maeng, J-H Lee, Y-G Suh, and S-J Chung. Development and Validation of Analytical Method for SH-1242 in the Rat and Mouse Plasma by Liquid Chromatography/Tandem Mass Spectrometry. Molecules. 2020;25(3):531.
  10. Y-K Song, JE Park, Y Oh, S Hyung, Y-S Jeong, M-S Kim, W Lee, and S-J Chung. Suppression of Canine ATP Binding Cassette ABCB1 in Madin-Darby Canine Kidney Type II Cells Unmasks Human ABCG2-Mediated Efflux of Olaparib. Journal of Pharmacology and Experimental Therapeutics. 2019;368(1):79.
  11. J-H Son, Y-S Jeong, J-H Lee, M-S Kim, K-R Lee, C-K Shim, Y-H Kim, and S-J Chung. Identification of metabolites of MDR-1339, an inhibitor of β-amyloid protein aggregation, and kinetic characterization of the major metabolites in rats. Journal of Pharmaceutical and Biomedical Analysis. 2018;151:61-70.
  12. S Hyung, Y-S Jeong, J Yeo, Y-K Song, M-S Kim, Y-J Im, H-J Maeng, and S-J Chung. Identification of the primary determining factor(s) governing the oral absorption of edaravone in rats. European Journal of Pharmaceutical Sciences. 2018;123:312-20.
  13. Y Oh, Y-S Jeong, M-S Kim, JS Min, G Ryoo, JE Park, Y Jun, Y-K Song, S-E Chun, S Han, SK Bae, S-J Chung, and W Lee. Inhibition of Organic Anion Transporting Polypeptide 1B1 and 1B3 by Betulinic Acid: Effects of Preincubation and Albumin in the Media. Journal of Pharmaceutical Sciences. 2018;107(6):1713-23.
  14. C-K Noh, J-H Lee, M-S Kim, H-J Maeng, and S-J Chung. Simultaneous quantification of volitinib and gefitinib in rat plasma by HPLC–MS/MS for application to a pharmacokinetic study in rats. Journal of Separation Science. 2017;40(19):3782-91.

Presentation

Poster

  • C-S Yim, M-S Kim, Y-S Jeong, S-Y Lee, H-M Ryu, W Lee, D-D Kim, S-J Chung, Specific Inhibition of the Distribution of Lobeglitazone to the Liver by Atorvastatin in Rats: Evidence for a Rat Organic Anion Transporting Polypeptide 1B2-Mediated Interaction in Hepatic Transport, 2018 International Conference on the Korean Society of Pharmaceutical Sciences and Technology, Busan, Korea (Nov. 2018).
  • C-S Yim, M-S Kim, Y-S Jeong, S-Y Lee, H-M Ryu, W Lee, D-D Kim, S-J Chung, rOatp1b2-Mediated Interaction in the Hepatic Uptake of Lobeglitazone by Atorvastatin, 2018 International Meeting on 22nd MDO and 33rd JSSX in Kanazawa, Japan (Oct. 2018).

Workshop participation

  • 2022: 3rd Korean Pharmacokinetics Bootcamp Workshop at Seoul National University, Seoul, Korea (1-day workshop)
  • 2019: 2nd Korean Pharmacokinetics Bootcamp Workshop at Seoul National University, Seoul, Korea (1.5-day workshop)
  • 2018: 1st Korean Pharmacokinetics Bootcamp Workshop at Seoul National University, Seoul, Korea (1.5-day workshop)
  • 2017: Simcyp Workshop “Model-informed drug development: Incorporating population variability into mechanistic prediction of PK and modeling” Busan, Korea (5-day workshop).

Honors and Awards

Skills

  • Physiologically-based pharmacokinetic modeling using Berkeley Madonna, WinNonlin, Python, R, MATLAB, and Simcyp
  • Non-compartmental and compartment model-based analysis
  • Quantitative analysis using HPLC-UV and HPLC-MS/MS
  • Protein bindings: Plasma protein binding assay using rapid equilibrium dialysis kit; Blood-to-plasma partition coefficient assay using depletion method
  • Animal experiments: Femoral vein and artery cannulation in rats; Jugular vein cannulation in rats; Tissue distribution study after intravenous infusion in rats; Pharmacokinetic analysis after intravenous bolus and oral administration in rats and mice
  • Nucleotide quantitation: qPCR; Nano-drop
  • Cell works: Subculture; Uptake assay; Bi-directional permeability assay; Cell counting; Viability assay using trypan blue exclusion assay

Research Interests

  • Pharmacokinetics
  • Physiologically-based pharmacokinetic modeling
  • Pharmacokinetic modeling

License

  • Registered pharmacist, Korea