I am learning popPK. I needed the executable popPK software, and found nlmixr2 ( https://nlmixr2.org/ ).
Since I want to record my learning curve, I will write every steps.
I installed NLMIXR2 on my Windows machine, and ran a sample code below:
library(nlmixr2)
# \donttest{one.cmt <- function() {
ini({
## You may label each parameter with a comment
tka <- 0.45 # Ka
tcl <- log(c(0, 2.7, 100)) # Log Cl
## This works with interactive models
## You may also label the preceding line with label("label text")
tv <- 3.45; label("log V")
## the label("Label name") works with all models
eta.ka ~ 0.6
eta.cl ~ 0.3
eta.v ~ 0.1
add.sd <- 0.7
prop.sd <- 0.01
})
model({
ka <- exp(tka + eta.ka)
cl <- exp(tcl + eta.cl)
v <- exp(tv + eta.v)
linCmt() ~ add(add.sd) + prop(prop.sd)
})
}fitF <- nlmixr(one.cmt, theo_sd, "focei")
fitS <- nlmixr(one.cmt, theo_sd, "saem")
# }
The results was the same as below:
→ optimizing duplicate expressions in EBE model...
[====|====|====|====|====|====|====|====|====|====] 100%; 0:00:00
→ compiling inner model...
✔ done
→ finding duplicate expressions in FD model...
[====|====|====|====|====|====|====|====|====|====] 100%; 0:00:00
→ optimizing duplicate expressions in FD model...
[====|====|====|====|====|====|====|====|====|====] 100%; 0:00:00
→ compiling EBE model...
✔ done
→ compiling events FD model...
✔ done
rxode2 2.0.12 using 10 threads (see ?getRxThreads)
no cache: create with `rxCreateCache()`
Key: U: Unscaled Parameters; X: Back-transformed parameters; G: Gill difference gradient approximation
F: Forward difference gradient approximation
C: Central difference gradient approximation
M: Mixed forward and central difference gradient approximation
Unscaled parameters for Omegas=chol(solve(omega));
Diagonals are transformed, as specified by foceiControl(diagXform=)
|-----+---------------+-----------+-----------+-----------+-----------|
| #| Objective Fun | tka | tcl | tv | add.sd |
|.....................| prop.sd | o1 | o2 | o3 |
| 1| 133.41448 | -0.7442 | -0.4283 | 1.000 | -0.5988 |
|.....................| -1.000 | -0.3452 | -0.2202 | 0.02807 |
| U| 133.41448 | 0.4500 | 0.9933 | 3.450 | 0.7000 |
|.....................| 0.01000 | 1.136 | 1.351 | 1.778 |
| X| 133.41448 | 1.568 | 2.700 | 31.50 | 0.7000 |
|.....................| 0.01000 | 1.136 | 1.351 | 1.778 |
| G| Gill Diff. | -0.9125 | -1.615 | -3.070 | 2.435 |
|.....................| -0.1592 | -11.82 | -35.27 | -34.85 |
| 2| 122.43055 | -0.7263 | -0.3968 | 1.060 | -0.6464 |
|.....................| -0.9969 | -0.1141 | 0.4692 | 0.7093 |
| U| 122.43055 | 0.4678 | 1.025 | 3.510 | 0.6833 |
|.....................| 0.01002 | 1.399 | 2.283 | 2.990 |
| X| 122.43055 | 1.597 | 2.787 | 33.45 | 0.6833 |
|.....................| 0.01002 | 1.399 | 2.283 | 2.990 |
| F| Forward Diff. | -0.9248 | 14.56 | 70.61 | -6.013 |
|.....................| -0.2357 | 14.20 | 16.75 | 14.05 |
| 3| 690.37789 | -0.7041 | -0.5837 | 0.1046 | -0.5874 |
|.....................| -0.9920 | -0.1913 | 0.5969 | 0.8706 |
| U| 690.37789 | 0.4901 | 0.8379 | 2.555 | 0.7040 |
|.....................| 0.01004 | 1.311 | 2.455 | 3.276 |
| X| 690.37789 | 1.633 | 2.311 | 12.87 | 0.7040 |
|.....................| 0.01004 | 1.311 | 2.455 | 3.276 |
| 4| 120.83482 | -0.7251 | -0.4157 | 0.9682 | -0.6386 |
|.....................| -0.9966 | -0.1326 | 0.4474 | 0.6911 |
| U| 120.83482 | 0.4690 | 1.006 | 3.418 | 0.6861 |
|.....................| 0.01002 | 1.378 | 2.253 | 2.957 |
| X| 120.83482 | 1.598 | 2.734 | 30.51 | 0.6861 |
|.....................| 0.01002 | 1.378 | 2.253 | 2.957 |
| F| Forward Diff. | 2.642 | -6.819 | -53.06 | -3.749 |
|.....................| -0.2091 | 13.15 | 15.49 | 9.370 |
| 5| 118.22220 | -0.7302 | -0.4140 | 1.019 | -0.6252 |
|.....................| -0.9960 | -0.1753 | 0.3888 | 0.6473 |
| U| 118.2222 | 0.4640 | 1.008 | 3.469 | 0.6908 |
|.....................| 0.01002 | 1.329 | 2.174 | 2.879 |
| X| 118.2222 | 1.590 | 2.739 | 32.12 | 0.6908 |
|.....................| 0.01002 | 1.329 | 2.174 | 2.879 |
| F| Forward Diff. | 0.01765 | 0.03756 | 11.87 | -1.578 |
|.....................| -0.1914 | 7.033 | 11.35 | 6.671 |
| 6| 117.74338 | -0.7307 | -0.4081 | 0.9753 | -0.6182 |
|.....................| -0.9950 | -0.2134 | 0.3198 | 0.6053 |
| U| 117.74338 | 0.4635 | 1.013 | 3.425 | 0.6932 |
|.....................| 0.01002 | 1.286 | 2.081 | 2.805 |
| X| 117.74338 | 1.590 | 2.755 | 30.73 | 0.6932 |
|.....................| 0.01002 | 1.286 | 2.081 | 2.805 |
| F| Forward Diff. | 1.126 | -2.103 | -36.64 | -0.2032 |
|.....................| -0.1718 | 3.311 | 7.046 | 4.162 |
| 7| 116.83266 | -0.7292 | -0.4104 | 1.027 | -0.6289 |
|.....................| -0.9934 | -0.2199 | 0.2482 | 0.5604 |
| U| 116.83266 | 0.4650 | 1.011 | 3.477 | 0.6895 |
|.....................| 0.01003 | 1.279 | 1.984 | 2.725 |
| X| 116.83266 | 1.592 | 2.749 | 32.37 | 0.6895 |
|.....................| 0.01003 | 1.279 | 1.984 | 2.725 |
| F| Forward Diff. | -0.2504 | 0.9953 | 17.45 | -0.8038 |
|.....................| -0.1904 | 2.235 | 1.806 | 1.747 |
| 8| 116.82421 | -0.7320 | -0.4335 | 1.004 | -0.6308 |
|.....................| -0.9811 | -0.2479 | 0.1991 | 0.4857 |
| U| 116.82421 | 0.4621 | 0.9881 | 3.454 | 0.6888 |
|.....................| 0.01009 | 1.247 | 1.918 | 2.592 |
| X| 116.82421 | 1.587 | 2.686 | 31.64 | 0.6888 |
|.....................| 0.01009 | 1.247 | 1.918 | 2.592 |
| F| Forward Diff. | -0.1447 | -6.916 | -6.236 | -0.5044 |
|.....................| -0.1786 | -0.6123 | -1.937 | -2.821 |
| 9| 116.82328 | -0.7312 | -0.3859 | 1.012 | -0.6244 |
|.....................| -0.9762 | -0.2578 | 0.1953 | 0.4848 |
| U| 116.82328 | 0.4630 | 1.036 | 3.462 | 0.6910 |
|.....................| 0.01012 | 1.236 | 1.913 | 2.590 |
| X| 116.82328 | 1.589 | 2.817 | 31.88 | 0.6910 |
|.....................| 0.01012 | 1.236 | 1.913 | 2.590 |
| F| Forward Diff. | -0.04912 | 6.546 | 2.755 | 0.3318 |
|.....................| -0.1750 | -1.425 | -2.138 | -2.844 |
| 10| 116.71967 | -0.7310 | -0.4062 | 1.004 | -0.6255 |
|.....................| -0.9757 | -0.2533 | 0.2019 | 0.4936 |
| U| 116.71967 | 0.4631 | 1.015 | 3.454 | 0.6907 |
|.....................| 0.01012 | 1.241 | 1.922 | 2.606 |
| X| 116.71967 | 1.589 | 2.760 | 31.61 | 0.6907 |
|.....................| 0.01012 | 1.241 | 1.922 | 2.606 |
| F| Forward Diff. | 0.05245 | 0.5800 | -5.549 | 0.03417 |
|.....................| -0.1793 | -1.379 | -1.783 | -2.382 |
| 11| 116.76081 | -0.7312 | -0.4084 | 1.025 | -0.6256 |
|.....................| -0.9750 | -0.2480 | 0.2088 | 0.5028 |
| U| 116.76081 | 0.4629 | 1.013 | 3.475 | 0.6906 |
|.....................| 0.01013 | 1.247 | 1.931 | 2.622 |
| X| 116.76081 | 1.589 | 2.754 | 32.30 | 0.6906 |
|.....................| 0.01013 | 1.247 | 1.931 | 2.622 |
| 12| 116.68638 | -0.7311 | -0.4071 | 1.012 | -0.6255 |
|.....................| -0.9754 | -0.2512 | 0.2047 | 0.4973 |
| U| 116.68638 | 0.4631 | 1.015 | 3.462 | 0.6907 |
|.....................| 0.01012 | 1.243 | 1.925 | 2.613 |
| X| 116.68638 | 1.589 | 2.758 | 31.89 | 0.6907 |
|.....................| 0.01012 | 1.243 | 1.925 | 2.613 |
| F| Forward Diff. | -0.1171 | 0.8023 | 1.821 | 0.1466 |
|.....................| -0.1772 | -1.209 | -1.628 | -2.214 |
| 13| 116.66590 | -0.7308 | -0.4093 | 1.007 | -0.6259 |
|.....................| -0.9749 | -0.2479 | 0.2092 | 0.5034 |
| U| 116.6659 | 0.4634 | 1.012 | 3.457 | 0.6905 |
|.....................| 0.01013 | 1.247 | 1.931 | 2.623 |
| X| 116.6659 | 1.589 | 2.752 | 31.73 | 0.6905 |
|.....................| 0.01013 | 1.247 | 1.931 | 2.623 |
| F| Forward Diff. | 0.005624 | -0.08427 | -2.657 | -0.2328 |
|.....................| -0.1868 | -0.7794 | -1.171 | -1.828 |
| 14| 116.65642 | -0.7308 | -0.4091 | 1.015 | -0.6253 |
|.....................| -0.9744 | -0.2457 | 0.2125 | 0.5085 |
| U| 116.65642 | 0.4634 | 1.013 | 3.465 | 0.6908 |
|.....................| 0.01013 | 1.249 | 1.936 | 2.633 |
| X| 116.65642 | 1.589 | 2.753 | 31.96 | 0.6908 |
|.....................| 0.01013 | 1.249 | 1.936 | 2.633 |
| F| Forward Diff. | -0.1383 | 0.4131 | 4.073 | 0.08716 |
|.....................| -0.1789 | -0.5559 | -1.040 | -1.502 |
| 15| 116.63997 | -0.7308 | -0.4103 | 1.009 | -0.6224 |
|.....................| -0.9723 | -0.2471 | 0.2126 | 0.5156 |
| U| 116.63997 | 0.4634 | 1.011 | 3.459 | 0.6917 |
|.....................| 0.01014 | 1.248 | 1.936 | 2.645 |
| X| 116.63997 | 1.589 | 2.749 | 31.78 | 0.6917 |
|.....................| 0.01014 | 1.248 | 1.936 | 2.645 |
| F| Forward Diff. | -0.01776 | -0.2763 | -1.122 | 0.3482 |
|.....................| -0.1800 | -1.153 | -0.9215 | -1.219 |
| 16| 116.63122 | -0.7311 | -0.4092 | 1.013 | -0.6250 |
|.....................| -0.9700 | -0.2411 | 0.2137 | 0.5215 |
| U| 116.63122 | 0.4631 | 1.012 | 3.463 | 0.6908 |
|.....................| 0.01015 | 1.254 | 1.938 | 2.656 |
| X| 116.63122 | 1.589 | 2.752 | 31.90 | 0.6908 |
|.....................| 0.01015 | 1.254 | 1.938 | 2.656 |
| F| Forward Diff. | -0.08259 | 0.2523 | 2.418 | 0.001797 |
|.....................| -0.1813 | -0.07887 | -0.8017 | -1.008 |
| 17| 116.62365 | -0.7316 | -0.4097 | 1.009 | -0.6275 |
|.....................| -0.9643 | -0.2434 | 0.2141 | 0.5277 |
| U| 116.62365 | 0.4626 | 1.012 | 3.459 | 0.6900 |
|.....................| 0.01018 | 1.252 | 1.938 | 2.667 |
| X| 116.62365 | 1.588 | 2.751 | 31.77 | 0.6900 |
|.....................| 0.01018 | 1.252 | 1.938 | 2.667 |
| F| Forward Diff. | -0.02682 | -0.1560 | -1.138 | -0.1936 |
|.....................| -0.1836 | -0.2595 | -0.6058 | -0.7101 |
| 18| 116.62110 | -0.7313 | -0.4099 | 1.012 | -0.6243 |
|.....................| -0.9598 | -0.2474 | 0.2179 | 0.5331 |
| U| 116.6211 | 0.4629 | 1.012 | 3.462 | 0.6911 |
|.....................| 0.01020 | 1.247 | 1.943 | 2.676 |
| X| 116.6211 | 1.589 | 2.750 | 31.87 | 0.6911 |
|.....................| 0.01020 | 1.247 | 1.943 | 2.676 |
| F| Forward Diff. | -0.08317 | -0.03138 | 1.785 | 0.4059 |
|.....................| -0.1634 | -1.291 | -0.3853 | -0.3083 |
| 19| 116.61622 | -0.7304 | -0.4100 | 1.009 | -0.6209 |
|.....................| -0.9534 | -0.2412 | 0.2189 | 0.5329 |
| U| 116.61622 | 0.4638 | 1.012 | 3.459 | 0.6923 |
|.....................| 0.01023 | 1.254 | 1.945 | 2.676 |
| X| 116.61622 | 1.590 | 2.750 | 31.79 | 0.6923 |
|.....................| 0.01023 | 1.254 | 1.945 | 2.676 |
| F| Forward Diff. | 0.03574 | -0.1737 | -0.5811 | 0.6410 |
|.....................| -0.1769 | -0.3995 | -0.2483 | -0.4417 |
| 20| 116.62087 | -0.7307 | -0.4085 | 1.014 | -0.6273 |
|.....................| -0.9505 | -0.2377 | 0.2207 | 0.5365 |
| U| 116.62087 | 0.4634 | 1.013 | 3.464 | 0.6900 |
|.....................| 0.01025 | 1.258 | 1.947 | 2.682 |
| X| 116.62087 | 1.590 | 2.754 | 31.93 | 0.6900 |
|.....................| 0.01025 | 1.258 | 1.947 | 2.682 |
| 21| 116.61504 | -0.7305 | -0.4094 | 1.011 | -0.6229 |
|.....................| -0.9528 | -0.2399 | 0.2197 | 0.5343 |
| U| 116.61504 | 0.4637 | 1.012 | 3.461 | 0.6916 |
|.....................| 0.01024 | 1.256 | 1.946 | 2.678 |
| X| 116.61504 | 1.590 | 2.752 | 31.85 | 0.6916 |
|.....................| 0.01024 | 1.256 | 1.946 | 2.678 |
| F| Forward Diff. | -0.005380 | 0.09139 | 1.199 | 0.3548 |
|.....................| -0.1630 | -0.3128 | -0.1618 | -0.3263 |
| 22| 116.61423 | -0.7306 | -0.4095 | 1.009 | -0.6248 |
|.....................| -0.9513 | -0.2394 | 0.2198 | 0.5352 |
| U| 116.61423 | 0.4635 | 1.012 | 3.459 | 0.6909 |
|.....................| 0.01024 | 1.256 | 1.946 | 2.680 |
| X| 116.61423 | 1.590 | 2.751 | 31.78 | 0.6909 |
|.....................| 0.01024 | 1.256 | 1.946 | 2.680 |
| F| Forward Diff. | 0.04298 | -0.07197 | -0.9845 | -0.1362 |
|.....................| -0.1840 | 0.09766 | -0.2390 | -0.3173 |
| 23| 116.61284 | -0.7312 | -0.4094 | 1.010 | -0.6250 |
|.....................| -0.9482 | -0.2397 | 0.2199 | 0.5360 |
| U| 116.61284 | 0.4630 | 1.012 | 3.460 | 0.6909 |
|.....................| 0.01026 | 1.256 | 1.946 | 2.682 |
| X| 116.61284 | 1.589 | 2.752 | 31.82 | 0.6909 |
|.....................| 0.01026 | 1.256 | 1.946 | 2.682 |
| F| Forward Diff. | -0.01562 | 0.03946 | 0.2731 | -0.1531 |
|.....................| -0.1815 | 0.07943 | -0.1421 | -0.2798 |
| 24| 116.61232 | -0.7312 | -0.4095 | 1.009 | -0.6239 |
|.....................| -0.9455 | -0.2399 | 0.2201 | 0.5375 |
| U| 116.61232 | 0.4630 | 1.012 | 3.459 | 0.6912 |
|.....................| 0.01027 | 1.256 | 1.946 | 2.684 |
| X| 116.61232 | 1.589 | 2.751 | 31.79 | 0.6912 |
|.....................| 0.01027 | 1.256 | 1.946 | 2.684 |
| F| Forward Diff. | 0.007006 | -0.06359 | -0.5821 | 0.09673 |
|.....................| -0.1769 | 0.1113 | -0.1188 | -0.2030 |
| 25| 116.61137 | -0.7306 | -0.4094 | 1.010 | -0.6243 |
|.....................| -0.9423 | -0.2404 | 0.2201 | 0.5384 |
| U| 116.61137 | 0.4636 | 1.012 | 3.460 | 0.6911 |
|.....................| 0.01029 | 1.255 | 1.946 | 2.686 |
| X| 116.61137 | 1.590 | 2.752 | 31.82 | 0.6911 |
|.....................| 0.01029 | 1.255 | 1.946 | 2.686 |
| F| Forward Diff. | 0.01818 | 0.04403 | 0.3297 | 0.2253 |
|.....................| -0.1810 | -0.3784 | -0.07828 | -0.1537 |
| 26| 116.61067 | -0.7307 | -0.4094 | 1.010 | -0.6252 |
|.....................| -0.9391 | -0.2398 | 0.2200 | 0.5389 |
| U| 116.61067 | 0.4635 | 1.012 | 3.460 | 0.6908 |
|.....................| 0.01030 | 1.256 | 1.946 | 2.687 |
| X| 116.61067 | 1.590 | 2.752 | 31.81 | 0.6908 |
|.....................| 0.01030 | 1.256 | 1.946 | 2.687 |
| F| Forward Diff. | 0.02236 | 0.02048 | 0.008892 | 0.1135 |
|.....................| -0.1799 | -0.3013 | -0.07552 | -0.1386 |
| 27| 116.61200 | -0.7311 | -0.4097 | 1.010 | -0.6271 |
|.....................| -0.9359 | -0.2346 | 0.2213 | 0.5413 |
| U| 116.612 | 0.4631 | 1.012 | 3.460 | 0.6901 |
|.....................| 0.01032 | 1.262 | 1.948 | 2.691 |
| X| 116.612 | 1.589 | 2.751 | 31.80 | 0.6901 |
|.....................| 0.01032 | 1.262 | 1.948 | 2.691 |
| 28| 116.61064 | -0.7308 | -0.4095 | 1.010 | -0.6258 |
|.....................| -0.9380 | -0.2381 | 0.2205 | 0.5397 |
| U| 116.61064 | 0.4634 | 1.012 | 3.460 | 0.6906 |
|.....................| 0.01031 | 1.258 | 1.947 | 2.688 |
| X| 116.61064 | 1.589 | 2.751 | 31.80 | 0.6906 |
|.....................| 0.01031 | 1.258 | 1.947 | 2.688 |
| F| Forward Diff. | 0.02159 | -0.01782 | -0.03858 | 0.09486 |
|.....................| -0.1871 | -0.1276 | -0.1289 | -0.04090 |
| 29| 116.61059 | -0.7309 | -0.4094 | 1.010 | -0.6262 |
|.....................| -0.9372 | -0.2375 | 0.2210 | 0.5399 |
| U| 116.61059 | 0.4633 | 1.012 | 3.460 | 0.6904 |
|.....................| 0.01031 | 1.259 | 1.947 | 2.688 |
| X| 116.61059 | 1.589 | 2.752 | 31.81 | 0.6904 |
|.....................| 0.01031 | 1.259 | 1.947 | 2.688 |
| C| Central Diff. | 0.001346 | -0.03041 | 0.02816 | -0.1573 |
|.....................| -0.1911 | 0.1540 | -0.1089 | -0.05880 |
| 30| 116.61019 | -0.7309 | -0.4093 | 1.010 | -0.6257 |
|.....................| -0.9364 | -0.2380 | 0.2213 | 0.5401 |
| U| 116.61019 | 0.4633 | 1.012 | 3.460 | 0.6906 |
|.....................| 0.01032 | 1.258 | 1.948 | 2.689 |
| X| 116.61019 | 1.589 | 2.752 | 31.81 | 0.6906 |
|.....................| 0.01032 | 1.258 | 1.948 | 2.689 |
| 31| 116.60950 | -0.7311 | -0.4092 | 1.010 | -0.6255 |
|.....................| -0.9325 | -0.2378 | 0.2209 | 0.5400 |
| U| 116.6095 | 0.4631 | 1.012 | 3.460 | 0.6907 |
|.....................| 0.01034 | 1.258 | 1.947 | 2.689 |
| X| 116.6095 | 1.589 | 2.752 | 31.81 | 0.6907 |
|.....................| 0.01034 | 1.258 | 1.947 | 2.689 |
| 32| 116.60794 | -0.7318 | -0.4089 | 1.011 | -0.6249 |
|.....................| -0.9184 | -0.2368 | 0.2194 | 0.5399 |
| U| 116.60794 | 0.4623 | 1.013 | 3.461 | 0.6909 |
|.....................| 0.01041 | 1.259 | 1.945 | 2.688 |
| X| 116.60794 | 1.588 | 2.753 | 31.83 | 0.6909 |
|.....................| 0.01041 | 1.259 | 1.945 | 2.688 |
| 33| 116.60696 | -0.7328 | -0.4084 | 1.011 | -0.6240 |
|.....................| -0.8992 | -0.2355 | 0.2173 | 0.5397 |
| U| 116.60696 | 0.4614 | 1.013 | 3.461 | 0.6912 |
|.....................| 0.01050 | 1.261 | 1.942 | 2.688 |
| X| 116.60696 | 1.586 | 2.754 | 31.86 | 0.6912 |
|.....................| 0.01050 | 1.261 | 1.942 | 2.688 |
| F| Forward Diff. | -0.1153 | 0.3832 | 1.748 | -0.04713 |
|.....................| -0.1874 | 0.5267 | -0.3414 | -0.07396 |
| 34| 116.59964 | -0.7323 | -0.4093 | 1.009 | -0.6220 |
|.....................| -0.8612 | -0.2345 | 0.2187 | 0.5363 |
| U| 116.59964 | 0.4619 | 1.012 | 3.459 | 0.6919 |
|.....................| 0.01069 | 1.262 | 1.944 | 2.682 |
| X| 116.59964 | 1.587 | 2.752 | 31.79 | 0.6919 |
|.....................| 0.01069 | 1.262 | 1.944 | 2.682 |
| F| Forward Diff. | -0.03304 | 0.003257 | -0.6570 | 0.2631 |
|.....................| -0.1864 | 0.6584 | -0.3035 | -0.3335 |
| 35| 116.59051 | -0.7291 | -0.4098 | 1.010 | -0.6234 |
|.....................| -0.8230 | -0.2363 | 0.2186 | 0.5375 |
| U| 116.59051 | 0.4651 | 1.012 | 3.460 | 0.6914 |
|.....................| 0.01088 | 1.260 | 1.944 | 2.684 |
| X| 116.59051 | 1.592 | 2.750 | 31.82 | 0.6914 |
|.....................| 0.01088 | 1.260 | 1.944 | 2.684 |
| 36| 116.57162 | -0.7198 | -0.4115 | 1.009 | -0.6260 |
|.....................| -0.7083 | -0.2375 | 0.2163 | 0.5389 |
| U| 116.57162 | 0.4744 | 1.010 | 3.459 | 0.6905 |
|.....................| 0.01146 | 1.259 | 1.941 | 2.687 |
| X| 116.57162 | 1.607 | 2.746 | 31.79 | 0.6905 |
|.....................| 0.01146 | 1.259 | 1.941 | 2.687 |
| 37| 116.54812 | -0.6848 | -0.4177 | 1.008 | -0.6365 |
|.....................| -0.2789 | -0.2441 | 0.2084 | 0.5452 |
| U| 116.54812 | 0.5094 | 1.004 | 3.458 | 0.6868 |
|.....................| 0.01361 | 1.251 | 1.930 | 2.698 |
| X| 116.54812 | 1.664 | 2.729 | 31.75 | 0.6868 |
|.....................| 0.01361 | 1.251 | 1.930 | 2.698 |
| F| Forward Diff. | 2.536 | -2.301 | -2.967 | -0.5818 |
|.....................| -0.2397 | -0.09478 | -0.7963 | 0.07297 |
| 38| 116.39163 | -0.6924 | -0.4203 | 1.011 | -0.6467 |
|.....................| 0.3056 | -0.2534 | 0.2038 | 0.5484 |
| U| 116.39163 | 0.5018 | 1.001 | 3.461 | 0.6832 |
|.....................| 0.01653 | 1.241 | 1.924 | 2.704 |
| X| 116.39163 | 1.652 | 2.722 | 31.83 | 0.6832 |
|.....................| 0.01653 | 1.241 | 1.924 | 2.704 |
| 39| 116.03517 | -0.7015 | -0.4408 | 1.002 | -0.6806 |
|.....................| 2.059 | -0.2820 | 0.1858 | 0.5584 |
| U| 116.03517 | 0.4927 | 0.9808 | 3.452 | 0.6714 |
|.....................| 0.02529 | 1.208 | 1.900 | 2.721 |
| X| 116.03517 | 1.637 | 2.667 | 31.57 | 0.6714 |
|.....................| 0.02529 | 1.208 | 1.900 | 2.721 |
| 40| 116.26977 | -0.7431 | -0.5179 | 0.9754 | -0.8151 |
|.....................| 9.072 | -0.3961 | 0.1154 | 0.5982 |
| U| 116.26977 | 0.4511 | 0.9037 | 3.425 | 0.6243 |
|.....................| 0.06036 | 1.078 | 1.805 | 2.792 |
| X| 116.26977 | 1.570 | 2.469 | 30.73 | 0.6243 |
|.....................| 0.06036 | 1.078 | 1.805 | 2.792 |
| F| Forward Diff. | 1.479 | -9.068 | -8.967 | -0.1062 |
|.....................| -0.4299 | -4.938 | -1.944 | 0.5378 |
| 41| 116.43852 | -0.7628 | -0.5280 | 0.9829 | -0.8546 |
|.....................| 11.41 | -0.4290 | 0.09762 | 0.6078 |
| U| 116.43852 | 0.4313 | 0.8936 | 3.433 | 0.6105 |
|.....................| 0.07205 | 1.041 | 1.781 | 2.809 |
| X| 116.43852 | 1.539 | 2.444 | 30.97 | 0.6105 |
|.....................| 0.07205 | 1.041 | 1.781 | 2.809 |
| 42| 115.23898 | -0.7277 | -0.4761 | 0.9956 | -0.7541 |
|.....................| 6.012 | -0.3433 | 0.1489 | 0.5792 |
| U| 115.23898 | 0.4665 | 0.9455 | 3.446 | 0.6456 |
|.....................| 0.04506 | 1.138 | 1.850 | 2.758 |
| X| 115.23898 | 1.594 | 2.574 | 31.36 | 0.6456 |
|.....................| 0.04506 | 1.138 | 1.850 | 2.758 |
| F| Forward Diff. | 0.3734 | -17.80 | -16.93 | 4.401 |
|.....................| -0.4572 | -12.94 | -3.125 | 1.012 |
| 43| 113.95191 | -0.7589 | -0.4500 | 1.047 | -0.8372 |
|.....................| 9.964 | -0.3651 | 0.1234 | 0.5971 |
| U| 113.95191 | 0.4353 | 0.9716 | 3.497 | 0.6166 |
|.....................| 0.06482 | 1.114 | 1.815 | 2.790 |
| X| 113.95191 | 1.545 | 2.642 | 33.03 | 0.6166 |
|.....................| 0.06482 | 1.114 | 1.815 | 2.790 |
| F| Forward Diff. | -1.276 | -8.477 | 36.59 | 9.955 |
|.....................| -0.1865 | -16.24 | -6.216 | 2.736 |
| 44| 114.11080 | -0.8130 | -0.3803 | 1.001 | -0.9868 |
|.....................| 13.91 | -0.4622 | 0.08739 | 0.7195 |
| U| 114.1108 | 0.3812 | 1.041 | 3.451 | 0.5642 |
|.....................| 0.08456 | 1.003 | 1.767 | 3.008 |
| X| 114.1108 | 1.464 | 2.833 | 31.53 | 0.5642 |
|.....................| 0.08456 | 1.003 | 1.767 | 3.008 |
| 45| 112.99333 | -0.7836 | -0.4136 | 1.009 | -0.9116 |
|.....................| 11.81 | -0.4032 | 0.1093 | 0.6531 |
| U| 112.99333 | 0.4106 | 1.008 | 3.459 | 0.5905 |
|.....................| 0.07405 | 1.070 | 1.796 | 2.890 |
| X| 112.99333 | 1.508 | 2.740 | 31.79 | 0.5905 |
|.....................| 0.07405 | 1.070 | 1.796 | 2.890 |
| F| Forward Diff. | -1.067 | -2.224 | 0.4394 | 11.10 |
|.....................| -0.05293 | -21.20 | -7.216 | 2.396 |
| 46| 111.42492 | -0.7683 | -0.3637 | 1.002 | -0.9523 |
|.....................| 9.968 | -0.2602 | 0.1684 | 0.6459 |
| U| 111.42492 | 0.4259 | 1.058 | 3.452 | 0.5763 |
|.....................| 0.06484 | 1.233 | 1.876 | 2.877 |
| X| 111.42492 | 1.531 | 2.880 | 31.57 | 0.5763 |
|.....................| 0.06484 | 1.233 | 1.876 | 2.877 |
| F| Forward Diff. | -0.4560 | 10.43 | -4.213 | 2.017 |
|.....................| -0.5728 | -3.133 | -2.337 | 2.918 |
| 47| 110.22906 | -0.7724 | -0.4408 | 1.022 | -1.016 |
|.....................| 11.81 | -0.2012 | 0.1898 | 0.6174 |
| U| 110.22906 | 0.4218 | 0.9807 | 3.472 | 0.5540 |
|.....................| 0.07407 | 1.300 | 1.905 | 2.826 |
| X| 110.22906 | 1.525 | 2.666 | 32.21 | 0.5540 |
|.....................| 0.07407 | 1.300 | 1.905 | 2.826 |
| F| Forward Diff. | -1.208 | -9.400 | 12.06 | 3.953 |
|.....................| -0.4291 | 3.676 | -1.474 | 2.209 |
| 48| 109.28496 | -0.7787 | -0.4131 | 0.9910 | -1.082 |
|.....................| 13.66 | -0.1851 | 0.1944 | 0.6126 |
| U| 109.28496 | 0.4155 | 1.008 | 3.441 | 0.5307 |
|.....................| 0.08331 | 1.318 | 1.911 | 2.818 |
| X| 109.28496 | 1.515 | 2.741 | 31.22 | 0.5307 |
|.....................| 0.08331 | 1.318 | 1.911 | 2.818 |
| F| Forward Diff. | -0.02901 | -3.661 | -20.35 | 6.346 |
|.....................| -0.2249 | 5.731 | -1.589 | 1.201 |
| 49| 108.10870 | -0.7878 | -0.3964 | 1.013 | -1.175 |
|.....................| 15.51 | -0.1898 | 0.1945 | 0.6146 |
| U| 108.1087 | 0.4063 | 1.025 | 3.463 | 0.4983 |
|.....................| 0.09255 | 1.313 | 1.912 | 2.821 |
| X| 108.1087 | 1.501 | 2.788 | 31.92 | 0.4983 |
|.....................| 0.09255 | 1.313 | 1.912 | 2.821 |
| 50| 107.37184 | -0.7981 | -0.3832 | 1.008 | -1.270 |
|.....................| 17.58 | -0.1865 | 0.1923 | 0.6187 |
| U| 107.37184 | 0.3961 | 1.038 | 3.458 | 0.4653 |
|.....................| 0.1029 | 1.317 | 1.909 | 2.829 |
| X| 107.37184 | 1.486 | 2.825 | 31.75 | 0.4653 |
|.....................| 0.1029 | 1.317 | 1.909 | 2.829 |
| 51| 106.69485 | -0.8190 | -0.3520 | 1.020 | -1.469 |
|.....................| 21.81 | -0.1862 | 0.1895 | 0.6258 |
| U| 106.69485 | 0.3752 | 1.070 | 3.470 | 0.3953 |
|.....................| 0.1241 | 1.317 | 1.905 | 2.841 |
| X| 106.69485 | 1.455 | 2.914 | 32.12 | 0.3953 |
|.....................| 0.1241 | 1.317 | 1.905 | 2.841 |
| F| Forward Diff. | -1.527 | 13.18 | 7.260 | 11.59 |
|.....................| 0.4292 | 4.108 | -2.364 | -0.1560 |
| 52| 105.34635 | -0.7597 | -0.3437 | 1.014 | -1.772 |
|.....................| 23.81 | -0.3009 | 0.2573 | 0.5106 |
| U| 105.34635 | 0.4345 | 1.078 | 3.464 | 0.2892 |
|.....................| 0.1340 | 1.187 | 1.996 | 2.636 |
| X| 105.34635 | 1.544 | 2.938 | 31.95 | 0.2892 |
|.....................| 0.1340 | 1.187 | 1.996 | 2.636 |
| F| Forward Diff. | 1.694 | 18.33 | -1.820 | 3.258 |
|.....................| 0.1785 | -7.542 | 1.531 | -3.438 |
| 53| 104.92085 | -0.7434 | -0.4288 | 1.020 | -1.865 |
|.....................| 25.42 | -0.2333 | 0.2809 | 0.5787 |
| U| 104.92085 | 0.4508 | 0.9928 | 3.470 | 0.2569 |
|.....................| 0.1421 | 1.263 | 2.028 | 2.757 |
| X| 104.92085 | 1.570 | 2.699 | 32.14 | 0.2569 |
|.....................| 0.1421 | 1.263 | 2.028 | 2.757 |
| F| Forward Diff. | 3.300 | -11.88 | -0.5184 | 0.2361 |
|.....................| 0.3384 | 0.2167 | 2.310 | -1.630 |
| 54| 104.80225 | -0.7764 | -0.4112 | 1.017 | -1.686 |
|.....................| 21.67 | -0.2260 | 0.2293 | 0.6712 |
| U| 104.80225 | 0.4178 | 1.010 | 3.467 | 0.3195 |
|.....................| 0.1234 | 1.272 | 1.959 | 2.922 |
| X| 104.80225 | 1.519 | 2.747 | 32.05 | 0.3195 |
|.....................| 0.1234 | 1.272 | 1.959 | 2.922 |
| F| Forward Diff. | 1.108 | -3.779 | 3.916 | 1.067 |
|.....................| -0.2337 | 0.7778 | -0.3866 | 2.205 |
| 55| 104.38543 | -0.7999 | -0.3814 | 1.016 | -1.805 |
|.....................| 23.77 | -0.2337 | 0.2229 | 0.6246 |
| U| 104.38543 | 0.3943 | 1.040 | 3.466 | 0.2778 |
|.....................| 0.1339 | 1.263 | 1.950 | 2.839 |
| X| 104.38543 | 1.483 | 2.830 | 32. | 0.2778 |
|.....................| 0.1339 | 1.263 | 1.950 | 2.839 |
| F| Forward Diff. | 0.1824 | 5.009 | 0.3600 | 0.3865 |
|.....................| 0.02636 | -0.2279 | -1.600 | 0.1688 |
| 56| 104.32981 | -0.8016 | -0.3985 | 1.015 | -1.805 |
|.....................| 23.74 | -0.2350 | 0.2589 | 0.6049 |
| U| 104.32981 | 0.3926 | 1.023 | 3.465 | 0.2779 |
|.....................| 0.1337 | 1.261 | 1.999 | 2.804 |
| X| 104.32981 | 1.481 | 2.782 | 31.98 | 0.2779 |
|.....................| 0.1337 | 1.261 | 1.999 | 2.804 |
| F| Forward Diff. | 0.04270 | -0.4550 | -0.4399 | 0.5042 |
|.....................| 0.02903 | -0.3006 | 0.8144 | -0.2880 |
| 57| 104.32320 | -0.8002 | -0.3975 | 1.016 | -1.810 |
|.....................| 23.69 | -0.2323 | 0.2456 | 0.6126 |
| U| 104.3232 | 0.3940 | 1.024 | 3.466 | 0.2761 |
|.....................| 0.1334 | 1.264 | 1.981 | 2.818 |
| X| 104.3232 | 1.483 | 2.784 | 32.00 | 0.2761 |
|.....................| 0.1334 | 1.264 | 1.981 | 2.818 |
| F| Forward Diff. | 0.1205 | -0.06260 | 0.2483 | -0.1176 |
|.....................| -0.005486 | -0.001306 | -0.1080 | -0.04867 |
| 58| 104.32320 | -0.8002 | -0.3975 | 1.016 | -1.810 |
|.....................| 23.69 | -0.2323 | 0.2456 | 0.6126 |
| U| 104.3232 | 0.3940 | 1.024 | 3.466 | 0.2761 |
|.....................| 0.1334 | 1.264 | 1.981 | 2.818 |
| X| 104.3232 | 1.483 | 2.784 | 32.00 | 0.2761 |
|.....................| 0.1334 | 1.264 | 1.981 | 2.818 |
calculating covariance matrix
[====|====|====|====|====|====|====|====|====|====] 0:00:00
done
→ Calculating residuals/tables
✔ done
→ compress origData in nlmixr2 object, save 5952
→ compress parHist in nlmixr2 object, save 2824
>
> fitS <- nlmixr(one.cmt, theo_sd, "saem")
ℹ parameter labels from comments will be replaced by 'label()'
→ loading into symengine environment...
→ pruning branches (`if`/`else`) of saem model...
✔ done
→ finding duplicate expressions in saem model...
[====|====|====|====|====|====|====|====|====|====] 0:00:00
✔ done
params: tka tcl tv V(eta.ka) V(eta.cl) V(eta.v) add.sd prop.sd
001: -0.080200 1.234448 3.580855 0.570000 0.322404 0.095000 2.465336 0.000111
002: 0.155871 1.166409 3.532752 0.541500 0.306284 0.090250 1.756233 0.000167
003: 0.393590 1.008472 3.474704 0.514425 0.290970 0.085737 0.834665 0.132042
004: 0.432322 0.973484 3.504374 0.488704 0.276421 0.081451 0.497621 0.172408
005: 0.532176 0.973719 3.506813 0.464269 0.262600 0.077378 0.341588 0.189561
006: 0.448131 1.014924 3.493418 0.441055 0.249470 0.073509 0.349916 0.160486
007: 0.407119 1.010794 3.484830 0.419002 0.236997 0.069834 0.288568 0.174087
008: 0.381553 0.989530 3.458048 0.398052 0.225147 0.066342 0.328027 0.160502
009: 0.363303 0.975426 3.468222 0.378150 0.213890 0.063025 0.315780 0.156026
010: 0.337004 1.019006 3.444429 0.359242 0.203195 0.059874 0.349065 0.147588
011: 0.420793 0.993875 3.461077 0.341280 0.193035 0.056880 0.304890 0.163691
012: 0.383775 0.996212 3.437767 0.324216 0.183384 0.054036 0.413778 0.135545
013: 0.335689 1.016572 3.438223 0.308005 0.174214 0.051334 0.328558 0.155219
014: 0.357823 0.992314 3.443296 0.305527 0.165504 0.048767 0.315997 0.157115
015: 0.382049 1.020540 3.451679 0.290251 0.157229 0.046329 0.278976 0.157087
016: 0.385127 1.035558 3.470487 0.275738 0.149367 0.044013 0.284319 0.158505
017: 0.381571 1.018722 3.473795 0.261952 0.141899 0.041812 0.308665 0.153730
018: 0.441336 0.994202 3.484597 0.286593 0.134804 0.039721 0.293638 0.141668
019: 0.404171 0.996810 3.483635 0.311929 0.128064 0.037735 0.298845 0.144124
020: 0.415838 1.014337 3.476448 0.368027 0.121660 0.035849 0.301057 0.148849
021: 0.402484 1.015811 3.481952 0.358848 0.115577 0.034056 0.292638 0.150243
022: 0.391277 1.022718 3.489560 0.387839 0.109799 0.032353 0.293342 0.148476
023: 0.508820 1.006878 3.497896 0.368447 0.104309 0.030736 0.301778 0.163374
024: 0.522605 1.024869 3.514102 0.350025 0.099093 0.029199 0.265107 0.166066
025: 0.490382 0.985421 3.507743 0.338200 0.094139 0.027739 0.282963 0.156156
026: 0.459087 1.025160 3.484027 0.343572 0.089432 0.026352 0.280383 0.157265
027: 0.396806 1.036532 3.470643 0.339124 0.084960 0.025034 0.287338 0.159896
028: 0.489037 0.999253 3.494059 0.322168 0.080712 0.023783 0.253138 0.156688
029: 0.498914 1.019650 3.474236 0.314876 0.076676 0.022594 0.347971 0.147454
030: 0.499508 1.015395 3.476929 0.349038 0.072843 0.021464 0.385760 0.146733
031: 0.407032 1.019296 3.481322 0.331586 0.069200 0.020391 0.270187 0.166484
032: 0.363138 1.008502 3.487945 0.315007 0.073880 0.019371 0.272866 0.158645
033: 0.403107 1.022812 3.481947 0.339358 0.070186 0.018403 0.256919 0.159488
034: 0.403277 1.031133 3.467922 0.367441 0.066676 0.017482 0.273260 0.153151
035: 0.356988 1.040711 3.463397 0.357645 0.063343 0.016608 0.267510 0.152096
036: 0.368753 1.022707 3.456159 0.339763 0.065359 0.015778 0.263698 0.159446
037: 0.353529 1.039461 3.459146 0.322775 0.065295 0.015757 0.323394 0.154857
038: 0.442326 1.023968 3.454390 0.354803 0.073849 0.014969 0.304630 0.151745
039: 0.445636 1.000566 3.480692 0.337063 0.070157 0.014220 0.263084 0.154606
040: 0.424053 0.998035 3.497009 0.341354 0.069939 0.013509 0.268253 0.159598
041: 0.378205 1.004284 3.492132 0.324287 0.066442 0.012834 0.269847 0.162117
042: 0.485735 0.996791 3.486485 0.384838 0.081145 0.012192 0.284632 0.153656
043: 0.387425 1.020300 3.469442 0.365596 0.077088 0.011583 0.294760 0.156750
044: 0.391308 1.030139 3.471357 0.347316 0.073233 0.011003 0.238619 0.161454
045: 0.413464 1.048462 3.467858 0.329950 0.069572 0.010453 0.296420 0.151770
046: 0.444986 1.020124 3.470669 0.348369 0.086979 0.009931 0.293734 0.153624
047: 0.437550 1.041527 3.456832 0.330951 0.082630 0.009434 0.279501 0.156401
048: 0.412384 1.023153 3.456453 0.325195 0.078499 0.008962 0.289614 0.151235
049: 0.365791 1.022745 3.465730 0.308935 0.074574 0.008514 0.244776 0.165255
050: 0.450867 0.999274 3.474666 0.293488 0.082317 0.008089 0.249341 0.174723
051: 0.434408 1.021848 3.466336 0.417156 0.081667 0.007684 0.261411 0.167196
052: 0.409713 1.018364 3.459585 0.396299 0.077584 0.007300 0.273692 0.159768
053: 0.452405 1.011674 3.471421 0.395850 0.073704 0.006935 0.246243 0.165660
054: 0.341767 1.016561 3.468694 0.399581 0.070019 0.006588 0.247898 0.168731
055: 0.368326 1.004881 3.469820 0.379601 0.066518 0.006259 0.239317 0.167094
056: 0.424987 1.004167 3.475780 0.360621 0.063192 0.006849 0.254220 0.163547
057: 0.400706 1.001019 3.492452 0.342590 0.063728 0.006506 0.237459 0.178385
058: 0.381804 1.002612 3.480131 0.328520 0.065239 0.006181 0.230982 0.166438
059: 0.415528 0.977369 3.474114 0.377385 0.079556 0.005872 0.257225 0.166862
060: 0.388652 0.989912 3.485805 0.393311 0.075578 0.006082 0.262712 0.172613
061: 0.456043 0.992509 3.484497 0.393077 0.071799 0.005912 0.277544 0.168302
062: 0.435333 1.026457 3.483141 0.373423 0.068209 0.006222 0.258587 0.173435
063: 0.462577 1.033468 3.475715 0.354752 0.084834 0.006529 0.297976 0.169636
064: 0.436649 1.025558 3.475024 0.347730 0.080593 0.006720 0.275017 0.152158
065: 0.427589 0.992274 3.460733 0.330343 0.076563 0.006384 0.272691 0.149834
066: 0.397307 1.031229 3.462192 0.313826 0.078617 0.007355 0.289555 0.142347
067: 0.383592 1.017982 3.457181 0.298135 0.074686 0.008658 0.256521 0.149924
068: 0.365475 1.012708 3.466301 0.284598 0.070951 0.008393 0.248230 0.169235
069: 0.368287 1.026489 3.461986 0.323666 0.070226 0.009215 0.273257 0.178218
070: 0.359712 1.016197 3.471960 0.345418 0.066714 0.008755 0.251484 0.172162
071: 0.371980 1.024975 3.464015 0.328147 0.063379 0.008317 0.258341 0.177765
072: 0.327993 1.004304 3.444457 0.311740 0.069739 0.007901 0.262495 0.164002
073: 0.409018 1.028198 3.471433 0.296153 0.070332 0.007506 0.270828 0.163620
074: 0.381015 1.003630 3.482971 0.285298 0.066815 0.007131 0.271372 0.168599
075: 0.436226 0.989450 3.507681 0.290109 0.087494 0.006774 0.244017 0.170677
076: 0.456478 1.024767 3.504780 0.275603 0.083119 0.006435 0.256026 0.167087
077: 0.498002 0.993457 3.500075 0.261823 0.078963 0.006114 0.293664 0.155784
078: 0.471491 0.994674 3.504558 0.298514 0.075015 0.005808 0.264593 0.166161
079: 0.495096 1.006077 3.520270 0.365493 0.071745 0.006089 0.240729 0.183161
080: 0.492989 1.015305 3.511031 0.347218 0.068158 0.006707 0.260197 0.180285
081: 0.479699 1.010491 3.511448 0.329857 0.067895 0.009134 0.255014 0.172428
082: 0.482646 0.982529 3.528616 0.321585 0.064500 0.011273 0.239416 0.173642
083: 0.492686 1.010793 3.516467 0.305506 0.070469 0.010709 0.249879 0.168040
084: 0.439794 1.035790 3.502281 0.290231 0.066946 0.010668 0.260129 0.169723
085: 0.485595 1.019877 3.525881 0.339669 0.063598 0.010134 0.253871 0.182322
086: 0.439234 1.012879 3.520300 0.322686 0.060418 0.009817 0.262724 0.170992
087: 0.429011 1.008374 3.498176 0.306551 0.057397 0.009326 0.261587 0.172534
088: 0.384407 1.002324 3.492044 0.316934 0.060285 0.011597 0.283676 0.166441
089: 0.403636 1.018073 3.482384 0.301087 0.057271 0.011386 0.240434 0.170610
090: 0.336065 1.020473 3.471586 0.286033 0.054407 0.010817 0.265818 0.170456
091: 0.341131 1.003554 3.448622 0.271731 0.055658 0.010276 0.357641 0.147777
092: 0.345032 1.029713 3.449917 0.310566 0.067517 0.009762 0.299167 0.153140
093: 0.325148 1.025246 3.444557 0.295038 0.064141 0.009274 0.269380 0.154724
094: 0.330734 1.044315 3.435450 0.280286 0.070752 0.008810 0.266642 0.159033
095: 0.363003 1.048239 3.457472 0.404852 0.068836 0.008370 0.249814 0.164973
096: 0.351314 1.026697 3.463116 0.384609 0.065394 0.007951 0.269932 0.166539
097: 0.417698 1.046124 3.475578 0.365379 0.062124 0.007554 0.255395 0.166728
098: 0.411300 1.037570 3.479924 0.347110 0.059018 0.007176 0.233299 0.170627
099: 0.372456 1.009531 3.466883 0.355804 0.056067 0.006817 0.241546 0.159117
100: 0.369050 1.004997 3.464355 0.338014 0.054032 0.006476 0.251899 0.163297
101: 0.314885 1.012833 3.447358 0.341560 0.062928 0.006153 0.257253 0.159282
102: 0.324727 1.002909 3.429398 0.324482 0.061687 0.005845 0.306811 0.144926
103: 0.405590 1.030967 3.443676 0.308258 0.058897 0.005817 0.280281 0.148560
104: 0.417396 1.019539 3.451152 0.335151 0.068628 0.005527 0.313910 0.155237
105: 0.410598 1.014794 3.445709 0.477864 0.073359 0.005250 0.287048 0.163309
106: 0.395624 1.014088 3.447282 0.453971 0.074232 0.004988 0.280439 0.160768
107: 0.431937 1.036136 3.452510 0.431272 0.079705 0.004738 0.269962 0.164737
108: 0.355694 1.038541 3.448956 0.409709 0.075720 0.004501 0.277225 0.167426
109: 0.324154 1.020657 3.456797 0.389223 0.085649 0.004402 0.274721 0.162562
110: 0.378289 1.016658 3.445335 0.369762 0.081366 0.004182 0.259090 0.156495
111: 0.357624 1.019487 3.449664 0.351274 0.087740 0.003973 0.266794 0.155543
112: 0.365122 1.009260 3.449891 0.333710 0.083353 0.003774 0.281518 0.153479
113: 0.362891 1.020479 3.454418 0.326131 0.079185 0.003586 0.283064 0.159130
114: 0.387399 1.024657 3.458002 0.309825 0.082104 0.003406 0.307998 0.150562
115: 0.400725 0.997315 3.450837 0.294334 0.089698 0.003660 0.273075 0.163230
116: 0.359051 1.018869 3.456884 0.324268 0.085213 0.003807 0.262052 0.170593
117: 0.345967 1.030213 3.459465 0.308055 0.086853 0.003617 0.270861 0.170705
118: 0.388528 1.020935 3.458283 0.292652 0.082510 0.004007 0.308748 0.159113
119: 0.343056 1.025998 3.457990 0.321450 0.078385 0.004811 0.249586 0.162135
120: 0.377992 1.017729 3.462410 0.338479 0.074466 0.005570 0.266309 0.150221
121: 0.389591 1.049514 3.454214 0.339401 0.070742 0.005292 0.287593 0.151085
122: 0.380021 1.015145 3.453369 0.348022 0.067205 0.005027 0.272911 0.156560
123: 0.421669 1.026486 3.449914 0.330621 0.078696 0.005113 0.276544 0.156568
124: 0.418823 1.056433 3.453089 0.382311 0.074761 0.005682 0.288317 0.155430
125: 0.413740 1.051391 3.453901 0.373165 0.071956 0.005967 0.298985 0.155828
126: 0.356224 1.045800 3.442607 0.416945 0.079029 0.006046 0.305526 0.150428
127: 0.383846 1.015327 3.438989 0.396098 0.094404 0.005916 0.327998 0.151626
128: 0.320842 1.024036 3.447935 0.376293 0.089684 0.008068 0.312531 0.151390
129: 0.374186 1.038683 3.456980 0.369015 0.085200 0.007664 0.290887 0.154846
130: 0.444962 1.053226 3.454937 0.361613 0.080940 0.007281 0.298090 0.151085
131: 0.422442 1.016042 3.449083 0.343532 0.082819 0.006917 0.332667 0.149319
132: 0.321971 0.997057 3.435174 0.326356 0.091286 0.006571 0.298869 0.152178
133: 0.344825 1.027585 3.438345 0.310038 0.086721 0.006242 0.315581 0.161261
134: 0.386126 1.022497 3.456403 0.294536 0.082385 0.005930 0.260784 0.166601
135: 0.325790 1.039720 3.442804 0.279809 0.078266 0.005634 0.269592 0.164849
136: 0.329346 1.019273 3.443558 0.265819 0.074353 0.005352 0.243334 0.159139
137: 0.381538 1.025959 3.447135 0.309032 0.070635 0.005085 0.262371 0.161163
138: 0.400204 1.020687 3.453610 0.301289 0.067103 0.004830 0.321012 0.150578
139: 0.443259 1.017864 3.467746 0.306217 0.063935 0.005250 0.337075 0.149774
140: 0.441060 1.026052 3.480852 0.307721 0.075377 0.004987 0.275676 0.170694
141: 0.400911 0.982982 3.490884 0.309071 0.071608 0.006213 0.293538 0.163674
142: 0.472783 0.979880 3.496205 0.308808 0.084920 0.005903 0.261640 0.171708
143: 0.418301 1.019483 3.501082 0.386744 0.081920 0.006103 0.251125 0.169680
144: 0.469328 1.026690 3.509949 0.367407 0.077824 0.005798 0.253426 0.171793
145: 0.444976 1.028270 3.496935 0.349037 0.073933 0.005508 0.243302 0.169387
146: 0.461145 1.038691 3.501162 0.343972 0.076094 0.005233 0.271529 0.164645
147: 0.374909 1.009371 3.493301 0.326773 0.072290 0.004971 0.245298 0.163398
148: 0.378493 1.015805 3.484517 0.310434 0.068675 0.004723 0.258421 0.164080
149: 0.360699 0.999846 3.478022 0.294913 0.077053 0.004487 0.276480 0.168147
150: 0.390610 1.014307 3.484025 0.280473 0.073201 0.004262 0.285711 0.168714
151: 0.367679 1.026221 3.473050 0.266449 0.069541 0.004049 0.248476 0.181861
152: 0.397140 1.029101 3.478783 0.222214 0.069635 0.002677 0.271004 0.169889
153: 0.368066 1.036516 3.481995 0.264028 0.058751 0.001950 0.273242 0.174414
154: 0.465145 1.045522 3.486323 0.255823 0.067329 0.001953 0.265100 0.171632
155: 0.400440 1.014720 3.482863 0.260138 0.056026 0.001759 0.264278 0.166410
156: 0.368532 1.042254 3.484664 0.225428 0.071833 0.001991 0.266711 0.174532
157: 0.387152 1.003944 3.488067 0.206466 0.063711 0.002608 0.257258 0.182580
158: 0.430197 1.043659 3.485704 0.240910 0.054424 0.002039 0.259490 0.171427
159: 0.365090 1.054743 3.490922 0.228702 0.056757 0.001745 0.254162 0.176943
160: 0.421273 1.023322 3.489792 0.323000 0.072370 0.001659 0.261857 0.174089
161: 0.393415 1.022011 3.492367 0.340264 0.069142 0.001971 0.258549 0.172431
162: 0.426993 1.053552 3.478907 0.289739 0.057257 0.002181 0.284755 0.163920
163: 0.427543 1.028926 3.472490 0.305621 0.052681 0.001632 0.310487 0.167682
164: 0.427665 1.027284 3.473954 0.262956 0.049013 0.002021 0.254470 0.170121
165: 0.467677 1.039030 3.487377 0.343739 0.052843 0.002042 0.253352 0.169409
166: 0.462835 1.060103 3.483973 0.400023 0.044313 0.002209 0.234457 0.183321
167: 0.447243 1.068388 3.490144 0.419106 0.055390 0.002571 0.234835 0.174304
168: 0.492949 1.058172 3.501123 0.308796 0.055318 0.002355 0.253544 0.172427
169: 0.399486 1.061310 3.493500 0.255754 0.069102 0.001530 0.262140 0.184781
170: 0.436574 1.004502 3.492637 0.264667 0.074579 0.001318 0.248730 0.170029
171: 0.365018 1.006221 3.488434 0.252857 0.079280 0.001479 0.259315 0.165050
172: 0.382561 1.057967 3.485895 0.272241 0.062204 0.001263 0.266398 0.170159
173: 0.403797 1.036741 3.482973 0.260609 0.073790 0.001964 0.260382 0.166111
174: 0.395593 1.026019 3.482193 0.198184 0.066713 0.002079 0.261102 0.172506
175: 0.410202 1.036114 3.471305 0.249934 0.066157 0.002672 0.283300 0.165790
176: 0.377541 1.050386 3.471764 0.254161 0.061054 0.002031 0.278539 0.177810
177: 0.372875 1.053343 3.480263 0.271767 0.072245 0.002221 0.270017 0.168271
178: 0.373462 1.051080 3.479481 0.269955 0.076189 0.002498 0.279873 0.162004
179: 0.412010 1.026165 3.479738 0.302120 0.096538 0.002074 0.351960 0.153966
180: 0.421617 1.030873 3.484757 0.197390 0.086831 0.002048 0.322540 0.166935
181: 0.421253 0.997796 3.474265 0.216973 0.073438 0.002149 0.274522 0.166066
182: 0.357995 1.008038 3.474191 0.264678 0.098510 0.001867 0.265244 0.171148
183: 0.390788 1.027715 3.470451 0.294650 0.080677 0.001656 0.299549 0.155638
184: 0.392367 1.002954 3.462997 0.312997 0.069337 0.001598 0.276307 0.161050
185: 0.343216 1.027116 3.456760 0.314436 0.063446 0.001634 0.263298 0.168647
186: 0.361703 1.024870 3.461698 0.303574 0.064537 0.001928 0.254199 0.164297
187: 0.377731 0.999045 3.466876 0.326866 0.067669 0.002260 0.281548 0.165060
188: 0.347327 1.040311 3.457392 0.323780 0.071513 0.002312 0.282035 0.168284
189: 0.414192 1.033745 3.459245 0.330039 0.068863 0.002409 0.302995 0.166624
190: 0.411818 1.024919 3.462331 0.237461 0.066700 0.002356 0.262629 0.167890
191: 0.344862 1.038877 3.459019 0.227031 0.064103 0.001887 0.258364 0.179816
192: 0.382866 1.036016 3.455064 0.240624 0.061459 0.002290 0.245410 0.177007
193: 0.364820 1.044668 3.455712 0.266510 0.068111 0.002113 0.270023 0.160282
194: 0.372897 1.025483 3.451500 0.268377 0.063991 0.002376 0.263792 0.170949
195: 0.315461 1.026722 3.456995 0.254691 0.052972 0.002210 0.253463 0.175961
196: 0.317282 1.019161 3.461605 0.283482 0.079424 0.001898 0.289975 0.174459
197: 0.289682 1.041829 3.462079 0.294732 0.055980 0.001861 0.253109 0.176786
198: 0.416667 1.027809 3.458068 0.367036 0.066937 0.002469 0.256698 0.162318
199: 0.345168 1.000516 3.458243 0.307555 0.067139 0.002524 0.252596 0.166990
200: 0.328714 1.035042 3.453722 0.243462 0.063952 0.003492 0.259109 0.174261
201: 0.319099 1.031143 3.456230 0.234509 0.068660 0.003732 0.265291 0.173199
202: 0.334101 1.031064 3.454350 0.235425 0.064881 0.003758 0.261339 0.174606
203: 0.353989 1.030670 3.454721 0.256021 0.062963 0.004048 0.264077 0.171658
204: 0.367774 1.025031 3.455621 0.266730 0.064202 0.003743 0.270214 0.168552
205: 0.370180 1.027266 3.454709 0.267984 0.066295 0.003658 0.276157 0.167079
206: 0.373118 1.029991 3.455727 0.269744 0.066718 0.003513 0.281675 0.167491
207: 0.367878 1.027882 3.455140 0.273647 0.066907 0.003397 0.278675 0.168459
208: 0.367217 1.026033 3.455425 0.272699 0.067363 0.003309 0.277642 0.168485
209: 0.368553 1.022693 3.455138 0.277870 0.068415 0.003390 0.278226 0.166999
210: 0.369842 1.020987 3.454925 0.276651 0.068055 0.003399 0.279101 0.166483
211: 0.369110 1.022186 3.455704 0.278040 0.069094 0.003318 0.279660 0.165605
212: 0.370286 1.023677 3.456335 0.275363 0.069161 0.003253 0.281665 0.164819
213: 0.371769 1.020959 3.456496 0.274336 0.069273 0.003172 0.279719 0.165361
214: 0.372425 1.020784 3.456284 0.273574 0.069765 0.003164 0.279619 0.165251
215: 0.372711 1.022062 3.456736 0.272177 0.069610 0.003204 0.279107 0.165323
216: 0.376185 1.020579 3.456932 0.276397 0.069012 0.003214 0.278494 0.165371
217: 0.377113 1.021873 3.456541 0.278935 0.068932 0.003267 0.279781 0.164858
218: 0.378301 1.023147 3.456046 0.279053 0.067891 0.003253 0.278943 0.165045
219: 0.378224 1.022463 3.454772 0.278359 0.067032 0.003271 0.279281 0.165046
220: 0.377562 1.022728 3.454422 0.275978 0.066601 0.003221 0.279228 0.165183
221: 0.376159 1.022764 3.454151 0.272973 0.066090 0.003223 0.278739 0.164972
222: 0.377080 1.022213 3.454494 0.272409 0.065985 0.003270 0.279291 0.164842
223: 0.379144 1.021642 3.454567 0.274446 0.065760 0.003306 0.279737 0.164045
224: 0.381077 1.021715 3.455114 0.275735 0.066244 0.003333 0.280843 0.163400
225: 0.382348 1.020482 3.455936 0.275135 0.066192 0.003392 0.280674 0.163422
226: 0.383246 1.019916 3.456544 0.277055 0.066404 0.003451 0.281028 0.163219
227: 0.383125 1.019886 3.456919 0.278711 0.065982 0.003495 0.280633 0.163392
228: 0.381574 1.020824 3.456626 0.279467 0.065619 0.003574 0.279989 0.163366
229: 0.379912 1.020739 3.456676 0.280952 0.065739 0.003674 0.279529 0.163100
230: 0.380116 1.020626 3.456639 0.280256 0.066049 0.003719 0.280503 0.162574
231: 0.381051 1.020735 3.456963 0.278354 0.065830 0.003753 0.280202 0.162520
232: 0.379688 1.020686 3.457251 0.278296 0.065791 0.003789 0.279691 0.162520
233: 0.380137 1.019741 3.457580 0.279881 0.065451 0.003825 0.279402 0.162477
234: 0.380171 1.019775 3.457790 0.280092 0.065202 0.003830 0.279173 0.162471
235: 0.380478 1.019753 3.457819 0.280294 0.065077 0.003794 0.279755 0.162373
236: 0.380982 1.020394 3.457834 0.280396 0.065473 0.003767 0.279792 0.162555
237: 0.381884 1.020565 3.457808 0.281672 0.065714 0.003769 0.279938 0.162517
238: 0.381361 1.020938 3.457889 0.282102 0.065929 0.003763 0.280328 0.162720
239: 0.381478 1.021764 3.457994 0.282571 0.065843 0.003752 0.280009 0.162948
240: 0.381213 1.021277 3.458138 0.283142 0.065754 0.003718 0.279543 0.163134
241: 0.381952 1.020557 3.458207 0.285303 0.066074 0.003710 0.279129 0.163234
242: 0.380891 1.020007 3.458098 0.286159 0.066468 0.003713 0.278844 0.163317
243: 0.379518 1.020469 3.457882 0.286517 0.066668 0.003736 0.278716 0.163287
244: 0.377838 1.020412 3.457635 0.285375 0.066949 0.003751 0.278881 0.163322
245: 0.377000 1.020204 3.457419 0.285480 0.066747 0.003762 0.278915 0.163472
246: 0.376890 1.020020 3.457439 0.285971 0.066694 0.003783 0.280463 0.163143
247: 0.375931 1.019753 3.457497 0.285804 0.066687 0.003775 0.280357 0.163144
248: 0.375421 1.019951 3.457390 0.285385 0.066450 0.003772 0.280628 0.163058
249: 0.374863 1.020044 3.457465 0.284752 0.066307 0.003772 0.280709 0.163202
250: 0.375313 1.020536 3.457393 0.285349 0.066477 0.003777 0.281011 0.162975
251: 0.375938 1.021210 3.457398 0.285829 0.066736 0.003764 0.281660 0.163013
252: 0.375813 1.021767 3.457384 0.287173 0.066605 0.003771 0.281597 0.163134
253: 0.375657 1.022002 3.457429 0.287476 0.066526 0.003781 0.281397 0.163153
254: 0.375799 1.022586 3.457513 0.287707 0.066601 0.003795 0.281072 0.163198
255: 0.375423 1.022954 3.457689 0.287546 0.066657 0.003824 0.281029 0.163208
256: 0.375613 1.022827 3.457813 0.288393 0.066510 0.003856 0.280702 0.163120
257: 0.375822 1.022365 3.457969 0.288615 0.066314 0.003852 0.280166 0.163195
258: 0.375466 1.022550 3.457675 0.289165 0.066443 0.003844 0.280533 0.163017
259: 0.375461 1.022287 3.457472 0.289334 0.066387 0.003831 0.280216 0.163054
260: 0.375378 1.022509 3.457546 0.290156 0.066363 0.003825 0.280133 0.163098
261: 0.375407 1.022578 3.457752 0.289820 0.066299 0.003826 0.279830 0.163026
262: 0.375543 1.022926 3.457795 0.289900 0.066486 0.003818 0.280718 0.162964
263: 0.375804 1.023484 3.457894 0.290485 0.066402 0.003836 0.280962 0.162946
264: 0.375860 1.023539 3.458118 0.290967 0.066133 0.003847 0.280905 0.163013
265: 0.376563 1.023619 3.458420 0.291428 0.066143 0.003856 0.281034 0.162961
266: 0.377384 1.023989 3.458642 0.292530 0.065980 0.003875 0.281063 0.162863
267: 0.377761 1.024101 3.458815 0.294148 0.066015 0.003880 0.280639 0.162903
268: 0.377903 1.023855 3.458787 0.294547 0.065874 0.003864 0.280360 0.162978
269: 0.379029 1.023430 3.458756 0.294431 0.065885 0.003862 0.280031 0.162978
270: 0.379729 1.023409 3.458557 0.294965 0.065993 0.003862 0.280154 0.162802
271: 0.380210 1.023354 3.458463 0.295315 0.065938 0.003865 0.280298 0.162729
272: 0.380166 1.022950 3.458415 0.295073 0.066031 0.003868 0.280313 0.162711
273: 0.380425 1.022950 3.458369 0.294905 0.066349 0.003876 0.281364 0.162488
274: 0.379902 1.023022 3.458436 0.294147 0.066405 0.003880 0.282065 0.162296
275: 0.379803 1.023001 3.458404 0.293983 0.066479 0.003869 0.281925 0.162283
276: 0.379326 1.023090 3.458553 0.294245 0.066625 0.003867 0.281854 0.162391
277: 0.379421 1.023343 3.458808 0.293743 0.066545 0.003863 0.281581 0.162596
278: 0.379156 1.023340 3.458856 0.293361 0.066485 0.003850 0.282014 0.162671
279: 0.378797 1.023208 3.458897 0.293938 0.066166 0.003836 0.282052 0.162806
280: 0.379100 1.023701 3.459084 0.293664 0.066058 0.003830 0.282161 0.162822
281: 0.378987 1.024108 3.459209 0.293999 0.066011 0.003827 0.282372 0.162820
282: 0.379187 1.024384 3.459343 0.295110 0.065982 0.003827 0.282623 0.162871
283: 0.379454 1.024351 3.459427 0.295565 0.065905 0.003827 0.282462 0.163053
284: 0.379193 1.024135 3.459384 0.296243 0.065881 0.003814 0.282121 0.163136
285: 0.379264 1.024092 3.459265 0.295993 0.065854 0.003809 0.282108 0.163237
286: 0.378977 1.024261 3.459155 0.296169 0.065887 0.003816 0.281869 0.163210
287: 0.378891 1.024588 3.459048 0.296216 0.065871 0.003827 0.282006 0.163207
288: 0.379052 1.024604 3.458939 0.295756 0.065841 0.003836 0.281750 0.163286
289: 0.379449 1.024531 3.458843 0.295623 0.065790 0.003841 0.281537 0.163314
290: 0.379150 1.024613 3.458807 0.295522 0.065719 0.003828 0.281579 0.163388
291: 0.379326 1.024863 3.458837 0.295863 0.065668 0.003827 0.281700 0.163281
292: 0.379054 1.025011 3.458801 0.296274 0.065677 0.003828 0.281502 0.163191
293: 0.379048 1.024859 3.458781 0.296662 0.065571 0.003821 0.281128 0.163180
294: 0.378719 1.025010 3.458678 0.297283 0.065496 0.003811 0.280766 0.163191
295: 0.378924 1.024769 3.458644 0.297913 0.065413 0.003804 0.280449 0.163131
296: 0.379058 1.024644 3.458740 0.297718 0.065482 0.003803 0.280612 0.163060
297: 0.379643 1.024733 3.458837 0.297997 0.065396 0.003809 0.280401 0.163049
298: 0.380006 1.024771 3.458915 0.298218 0.065253 0.003812 0.279993 0.163118
299: 0.380503 1.024788 3.458921 0.298511 0.065220 0.003797 0.279674 0.163135
300: 0.380818 1.024821 3.459102 0.299219 0.065170 0.003795 0.279588 0.163111
301: 0.381175 1.024771 3.459240 0.298960 0.065174 0.003798 0.279907 0.163088
302: 0.381489 1.024921 3.459239 0.298826 0.065162 0.003804 0.279874 0.163084
303: 0.381462 1.025100 3.459261 0.298990 0.065055 0.003809 0.279947 0.162980
304: 0.381761 1.025273 3.459284 0.299704 0.064903 0.003812 0.280175 0.162926
305: 0.381330 1.025034 3.459380 0.300239 0.064988 0.003830 0.280222 0.162886
306: 0.380904 1.024849 3.459341 0.300199 0.065064 0.003847 0.280127 0.162869
307: 0.381076 1.024947 3.459220 0.299998 0.065162 0.003846 0.280441 0.162858
308: 0.380614 1.024825 3.459130 0.300547 0.065142 0.003849 0.280258 0.162888
309: 0.380802 1.024800 3.459050 0.300816 0.065174 0.003860 0.280434 0.162834
310: 0.381269 1.024628 3.459002 0.301319 0.065366 0.003858 0.281254 0.162709
311: 0.381230 1.024732 3.459043 0.301614 0.065383 0.003849 0.281272 0.162682
312: 0.381260 1.024707 3.458991 0.302336 0.065493 0.003847 0.281365 0.162562
313: 0.380782 1.024426 3.458951 0.302477 0.065459 0.003845 0.281224 0.162651
314: 0.380730 1.024339 3.458970 0.302720 0.065399 0.003842 0.281004 0.162686
315: 0.380856 1.024396 3.459053 0.302810 0.065351 0.003836 0.280832 0.162753
316: 0.381114 1.024377 3.459063 0.303339 0.065291 0.003829 0.280494 0.162775
317: 0.381415 1.024445 3.459124 0.303030 0.065349 0.003825 0.280272 0.162766
318: 0.381511 1.024458 3.459155 0.302712 0.065296 0.003813 0.280237 0.162738
319: 0.381652 1.024507 3.459137 0.302470 0.065256 0.003809 0.280103 0.162731
320: 0.381171 1.024498 3.459026 0.302871 0.065173 0.003799 0.279932 0.162801
321: 0.380596 1.024525 3.458898 0.302853 0.065131 0.003802 0.279868 0.162839
322: 0.380453 1.024546 3.458725 0.302994 0.065056 0.003803 0.279699 0.162830
323: 0.379984 1.024416 3.458682 0.303115 0.065024 0.003810 0.279472 0.162814
324: 0.379852 1.024497 3.458679 0.303507 0.065170 0.003802 0.279448 0.162776
325: 0.379697 1.024720 3.458597 0.303589 0.065231 0.003801 0.279367 0.162769
326: 0.379461 1.024565 3.458505 0.303733 0.065304 0.003791 0.279072 0.162791
327: 0.379630 1.024605 3.458497 0.304160 0.065286 0.003793 0.278926 0.162769
328: 0.379985 1.024822 3.458514 0.304448 0.065259 0.003791 0.278794 0.162841
329: 0.380302 1.024914 3.458554 0.304330 0.065300 0.003794 0.278598 0.162906
330: 0.380026 1.025031 3.458556 0.304265 0.065263 0.003800 0.278548 0.162991
331: 0.380061 1.025213 3.458510 0.304046 0.065257 0.003798 0.278499 0.163057
332: 0.380097 1.024958 3.458529 0.303880 0.065188 0.003797 0.278359 0.163065
333: 0.379732 1.024881 3.458432 0.304127 0.065158 0.003797 0.278082 0.163096
334: 0.379506 1.024653 3.458330 0.304224 0.065125 0.003798 0.278081 0.163079
335: 0.379396 1.024779 3.458249 0.304693 0.065077 0.003792 0.277970 0.163040
336: 0.378923 1.024843 3.458144 0.304545 0.065105 0.003798 0.277871 0.163037
337: 0.378597 1.025088 3.458008 0.304884 0.065167 0.003802 0.277966 0.163020
338: 0.378670 1.025310 3.457933 0.304926 0.065269 0.003802 0.278040 0.162966
339: 0.378354 1.025558 3.457862 0.304707 0.065216 0.003800 0.277950 0.163022
340: 0.378241 1.025538 3.457820 0.304343 0.065184 0.003799 0.277913 0.163034
341: 0.378212 1.025561 3.457773 0.303979 0.065237 0.003795 0.277943 0.163083
342: 0.378031 1.025464 3.457792 0.303974 0.065217 0.003795 0.277679 0.163110
343: 0.377583 1.025475 3.457834 0.303700 0.065190 0.003788 0.277434 0.163162
344: 0.377880 1.025438 3.457887 0.303940 0.065200 0.003787 0.277340 0.163165
345: 0.378004 1.025475 3.457944 0.303722 0.065109 0.003798 0.277223 0.163083
346: 0.377837 1.025511 3.457948 0.303774 0.065132 0.003794 0.277057 0.163036
347: 0.377948 1.025474 3.457852 0.303700 0.065180 0.003809 0.277231 0.162955
348: 0.377643 1.025572 3.457716 0.303535 0.065104 0.003819 0.277500 0.162988
349: 0.377982 1.025519 3.457609 0.303912 0.065070 0.003828 0.277489 0.162961
350: 0.377863 1.025355 3.457568 0.304264 0.065091 0.003833 0.277580 0.162953
351: 0.377783 1.025509 3.457452 0.304330 0.065115 0.003835 0.277642 0.162952
352: 0.377548 1.025533 3.457378 0.304861 0.065092 0.003839 0.277438 0.163028
353: 0.377277 1.025708 3.457289 0.305230 0.065047 0.003846 0.277311 0.163076
354: 0.377171 1.025774 3.457151 0.305287 0.064989 0.003862 0.277169 0.163051
355: 0.377548 1.025714 3.457074 0.305546 0.064886 0.003877 0.277514 0.162982
356: 0.377363 1.025618 3.457062 0.305239 0.064882 0.003878 0.277537 0.163027
357: 0.377484 1.025703 3.457041 0.305154 0.064847 0.003874 0.277558 0.163067
358: 0.377315 1.025685 3.457106 0.305037 0.064821 0.003867 0.277663 0.163018
359: 0.377343 1.025836 3.457124 0.304984 0.064809 0.003856 0.277517 0.163079
360: 0.377326 1.025826 3.457137 0.304952 0.064794 0.003852 0.277495 0.163071
361: 0.377165 1.025774 3.457137 0.304485 0.064821 0.003849 0.277491 0.163127
362: 0.377233 1.025734 3.457169 0.304358 0.064786 0.003846 0.277480 0.163096
363: 0.377264 1.025629 3.457211 0.304475 0.064716 0.003843 0.277273 0.163096
364: 0.377144 1.025671 3.457245 0.304507 0.064611 0.003845 0.277061 0.163113
365: 0.377069 1.025604 3.457279 0.304290 0.064574 0.003853 0.276954 0.163151
366: 0.377373 1.025625 3.457298 0.304187 0.064594 0.003854 0.276816 0.163144
367: 0.377541 1.025744 3.457322 0.303936 0.064564 0.003859 0.276932 0.163114
368: 0.377790 1.025953 3.457319 0.304126 0.064528 0.003868 0.276950 0.163121
369: 0.377851 1.025949 3.457367 0.304525 0.064527 0.003871 0.276911 0.163118
370: 0.377876 1.026105 3.457401 0.304702 0.064493 0.003879 0.277004 0.163099
371: 0.377521 1.026141 3.457290 0.304845 0.064469 0.003882 0.277126 0.163031
372: 0.377376 1.026195 3.457183 0.305038 0.064473 0.003885 0.277153 0.163056
373: 0.377128 1.026286 3.457003 0.305196 0.064459 0.003888 0.277168 0.163112
374: 0.376987 1.026265 3.456855 0.305345 0.064460 0.003886 0.277278 0.163070
375: 0.376697 1.026227 3.456749 0.305335 0.064408 0.003887 0.277276 0.163065
376: 0.376603 1.026277 3.456703 0.305183 0.064427 0.003888 0.277227 0.163064
377: 0.376644 1.026283 3.456731 0.305187 0.064427 0.003884 0.277164 0.163058
378: 0.376499 1.026140 3.456658 0.305366 0.064405 0.003879 0.277067 0.163098
379: 0.376324 1.025971 3.456690 0.305579 0.064410 0.003872 0.276868 0.163113
380: 0.375939 1.026123 3.456621 0.305583 0.064385 0.003869 0.276797 0.163150
381: 0.375625 1.026147 3.456558 0.305839 0.064403 0.003865 0.276951 0.163124
382: 0.375589 1.026128 3.456521 0.305869 0.064400 0.003860 0.276903 0.163123
383: 0.375740 1.026100 3.456504 0.305885 0.064376 0.003867 0.276830 0.163096
384: 0.375665 1.026057 3.456527 0.305705 0.064377 0.003866 0.276715 0.163090
385: 0.375645 1.026085 3.456549 0.305761 0.064359 0.003868 0.276562 0.163114
386: 0.375690 1.026215 3.456585 0.305651 0.064442 0.003867 0.276808 0.163043
387: 0.375923 1.026210 3.456637 0.305452 0.064476 0.003870 0.276926 0.162997
388: 0.376103 1.026260 3.456680 0.305547 0.064456 0.003869 0.277136 0.162939
389: 0.376097 1.026159 3.456669 0.305568 0.064487 0.003863 0.277271 0.162909
390: 0.376078 1.026192 3.456636 0.305682 0.064489 0.003862 0.277231 0.162868
391: 0.376098 1.026200 3.456609 0.305754 0.064464 0.003859 0.277168 0.162841
392: 0.376494 1.026321 3.456629 0.306089 0.064383 0.003858 0.277182 0.162887
393: 0.376424 1.026338 3.456619 0.306699 0.064308 0.003853 0.277183 0.162915
394: 0.376282 1.026384 3.456571 0.306657 0.064231 0.003850 0.277040 0.162947
395: 0.376629 1.026501 3.456582 0.306577 0.064176 0.003844 0.277022 0.162946
396: 0.376774 1.026673 3.456636 0.306700 0.064177 0.003838 0.277168 0.162907
397: 0.376942 1.026687 3.456678 0.306983 0.064183 0.003846 0.277082 0.162882
398: 0.377025 1.026667 3.456697 0.307171 0.064220 0.003847 0.277005 0.162878
399: 0.377044 1.026553 3.456708 0.307476 0.064252 0.003847 0.277070 0.162865
400: 0.377057 1.026718 3.456682 0.307692 0.064199 0.003851 0.277055 0.162849
401: 0.377064 1.026877 3.456669 0.307631 0.064246 0.003855 0.277256 0.162820
402: 0.376906 1.026880 3.456681 0.307795 0.064237 0.003862 0.277435 0.162761
403: 0.377231 1.026792 3.456699 0.307706 0.064267 0.003866 0.277531 0.162717
404: 0.377483 1.026846 3.456683 0.307488 0.064249 0.003860 0.277675 0.162686
405: 0.377551 1.026932 3.456732 0.307556 0.064280 0.003856 0.277656 0.162706
406: 0.377759 1.026959 3.456738 0.307692 0.064256 0.003857 0.277609 0.162723
407: 0.377943 1.026954 3.456757 0.307667 0.064325 0.003855 0.277585 0.162721
408: 0.377947 1.027111 3.456783 0.307652 0.064385 0.003859 0.277869 0.162734
409: 0.377712 1.027109 3.456753 0.307449 0.064381 0.003864 0.277782 0.162763
410: 0.377707 1.027217 3.456703 0.307284 0.064357 0.003871 0.277806 0.162778
411: 0.377670 1.026985 3.456667 0.307440 0.064476 0.003880 0.278130 0.162726
412: 0.377720 1.027052 3.456605 0.307241 0.064509 0.003881 0.278257 0.162706
413: 0.377592 1.027071 3.456525 0.306714 0.064525 0.003880 0.278218 0.162723
414: 0.377478 1.027095 3.456517 0.306692 0.064471 0.003878 0.278232 0.162708
415: 0.377712 1.027125 3.456499 0.306896 0.064440 0.003878 0.278196 0.162691
416: 0.377788 1.027293 3.456475 0.306832 0.064396 0.003874 0.278188 0.162729
417: 0.377796 1.027407 3.456415 0.307144 0.064425 0.003873 0.278342 0.162709
418: 0.377485 1.027501 3.456365 0.307187 0.064465 0.003874 0.278336 0.162736
419: 0.377427 1.027622 3.456285 0.307343 0.064431 0.003879 0.278346 0.162703
420: 0.377435 1.027629 3.456286 0.307432 0.064477 0.003874 0.278347 0.162639
421: 0.377204 1.027674 3.456271 0.307387 0.064467 0.003871 0.278242 0.162632
422: 0.377391 1.027606 3.456284 0.307559 0.064479 0.003871 0.278081 0.162611
423: 0.377404 1.027590 3.456300 0.307525 0.064507 0.003865 0.278190 0.162570
424: 0.377304 1.027584 3.456275 0.307510 0.064585 0.003860 0.278134 0.162575
425: 0.377596 1.027568 3.456299 0.307453 0.064630 0.003857 0.278291 0.162602
426: 0.377698 1.027644 3.456347 0.307439 0.064678 0.003855 0.278325 0.162596
427: 0.377664 1.027602 3.456387 0.307460 0.064764 0.003856 0.278422 0.162549
428: 0.377392 1.027624 3.456347 0.307379 0.064770 0.003859 0.278367 0.162559
429: 0.377472 1.027570 3.456326 0.307314 0.064762 0.003862 0.278232 0.162566
430: 0.377469 1.027593 3.456331 0.307179 0.064826 0.003864 0.278249 0.162544
431: 0.377344 1.027623 3.456319 0.307033 0.064855 0.003863 0.278242 0.162522
432: 0.377260 1.027715 3.456316 0.307052 0.064841 0.003859 0.278267 0.162538
433: 0.377266 1.027806 3.456290 0.307009 0.064831 0.003857 0.278437 0.162480
434: 0.377172 1.027809 3.456316 0.307243 0.064871 0.003857 0.278491 0.162429
435: 0.377243 1.027773 3.456327 0.307494 0.064894 0.003854 0.278567 0.162403
436: 0.377356 1.027712 3.456359 0.307766 0.064944 0.003852 0.279004 0.162325
437: 0.377435 1.027711 3.456341 0.308198 0.064964 0.003848 0.278999 0.162335
438: 0.377500 1.027866 3.456316 0.308440 0.064976 0.003845 0.279037 0.162364
439: 0.377383 1.027937 3.456289 0.308536 0.064991 0.003844 0.279018 0.162358
440: 0.377100 1.028000 3.456262 0.308449 0.064960 0.003842 0.279015 0.162369
441: 0.376985 1.027998 3.456239 0.308554 0.064987 0.003844 0.278889 0.162357
442: 0.376815 1.028053 3.456234 0.308614 0.064957 0.003842 0.278710 0.162372
443: 0.376843 1.028038 3.456233 0.308731 0.065008 0.003836 0.278737 0.162344
444: 0.376791 1.028028 3.456242 0.308702 0.065044 0.003832 0.278714 0.162363
445: 0.376791 1.028004 3.456216 0.308863 0.065123 0.003825 0.278871 0.162350
446: 0.376708 1.028001 3.456185 0.308992 0.065172 0.003820 0.278872 0.162369
447: 0.376891 1.027916 3.456196 0.308832 0.065220 0.003815 0.278898 0.162369
448: 0.376844 1.027949 3.456173 0.308432 0.065243 0.003814 0.278942 0.162380
449: 0.376852 1.028018 3.456258 0.308332 0.065220 0.003816 0.278853 0.162415
450: 0.376937 1.027946 3.456318 0.308229 0.065178 0.003817 0.278833 0.162426
451: 0.377035 1.027990 3.456351 0.308393 0.065125 0.003822 0.278788 0.162425
452: 0.377012 1.028080 3.456338 0.308340 0.065151 0.003819 0.278829 0.162398
453: 0.376869 1.028085 3.456313 0.308262 0.065160 0.003814 0.278933 0.162347
454: 0.376675 1.028226 3.456259 0.308203 0.065155 0.003810 0.278900 0.162331
455: 0.376758 1.028284 3.456225 0.308237 0.065114 0.003807 0.278888 0.162329
456: 0.376562 1.028262 3.456235 0.308503 0.065117 0.003805 0.278742 0.162355
457: 0.376331 1.028214 3.456237 0.308770 0.065090 0.003801 0.278614 0.162386
458: 0.376359 1.028249 3.456298 0.309034 0.065060 0.003798 0.278534 0.162432
459: 0.376319 1.028355 3.456320 0.308990 0.065034 0.003798 0.278638 0.162437
460: 0.376178 1.028415 3.456292 0.308800 0.065010 0.003795 0.278842 0.162425
461: 0.375980 1.028517 3.456267 0.308718 0.064954 0.003795 0.278798 0.162457
462: 0.376086 1.028573 3.456283 0.308752 0.064942 0.003795 0.278716 0.162464
463: 0.376105 1.028631 3.456275 0.308526 0.064901 0.003796 0.278669 0.162496
464: 0.376117 1.028664 3.456286 0.308444 0.064903 0.003792 0.278586 0.162523
465: 0.376015 1.028526 3.456284 0.308194 0.064931 0.003787 0.278551 0.162543
466: 0.376087 1.028578 3.456262 0.308167 0.064940 0.003784 0.278511 0.162530
467: 0.375938 1.028606 3.456229 0.308025 0.064942 0.003784 0.278354 0.162520
468: 0.376105 1.028651 3.456211 0.308114 0.064946 0.003784 0.278269 0.162536
469: 0.376156 1.028725 3.456198 0.308408 0.064964 0.003782 0.278292 0.162523
470: 0.376023 1.028791 3.456168 0.308475 0.064986 0.003780 0.278327 0.162503
471: 0.375817 1.028817 3.456139 0.308647 0.065001 0.003777 0.278225 0.162527
472: 0.375891 1.028787 3.456160 0.308756 0.064974 0.003774 0.278150 0.162560
473: 0.375696 1.028797 3.456171 0.308584 0.064954 0.003773 0.278031 0.162583
474: 0.375656 1.028785 3.456195 0.308466 0.064954 0.003770 0.277973 0.162624
475: 0.375691 1.028852 3.456222 0.308388 0.065021 0.003767 0.278118 0.162604
476: 0.375697 1.028850 3.456202 0.308750 0.065026 0.003764 0.278052 0.162600
477: 0.375589 1.028859 3.456175 0.308778 0.064994 0.003764 0.277988 0.162590
478: 0.375437 1.028834 3.456164 0.308711 0.065015 0.003761 0.277983 0.162587
479: 0.375595 1.028881 3.456181 0.308659 0.065127 0.003760 0.278119 0.162585
480: 0.375586 1.028893 3.456235 0.308508 0.065185 0.003761 0.278237 0.162604
481: 0.375684 1.028868 3.456265 0.308338 0.065131 0.003759 0.278167 0.162614
482: 0.375884 1.028822 3.456262 0.308404 0.065104 0.003762 0.278071 0.162644
483: 0.375777 1.028735 3.456255 0.308641 0.065073 0.003761 0.278016 0.162649
484: 0.375871 1.028679 3.456251 0.308924 0.065005 0.003759 0.277902 0.162680
485: 0.375988 1.028697 3.456292 0.309214 0.064991 0.003757 0.278140 0.162655
486: 0.376109 1.028724 3.456310 0.309192 0.065011 0.003756 0.278225 0.162627
487: 0.376315 1.028660 3.456379 0.309204 0.065044 0.003757 0.278300 0.162598
488: 0.376315 1.028568 3.456432 0.309146 0.065074 0.003758 0.278184 0.162599
489: 0.376450 1.028484 3.456454 0.309282 0.065058 0.003761 0.278084 0.162596
490: 0.376535 1.028539 3.456471 0.309306 0.065015 0.003762 0.278100 0.162598
491: 0.376317 1.028590 3.456490 0.309190 0.065010 0.003763 0.278019 0.162642
492: 0.376387 1.028610 3.456521 0.309156 0.065001 0.003767 0.277921 0.162681
493: 0.376340 1.028632 3.456555 0.309063 0.064955 0.003770 0.277850 0.162719
494: 0.376380 1.028644 3.456585 0.308814 0.064903 0.003770 0.277797 0.162723
495: 0.376532 1.028614 3.456637 0.308922 0.064882 0.003766 0.277711 0.162731
496: 0.376596 1.028660 3.456656 0.308824 0.064895 0.003766 0.277713 0.162727
497: 0.376473 1.028655 3.456708 0.308917 0.064863 0.003766 0.277612 0.162761
498: 0.376494 1.028650 3.456719 0.308897 0.064865 0.003763 0.277525 0.162765
499: 0.376629 1.028642 3.456693 0.309118 0.064908 0.003758 0.277439 0.162785
500: 0.376625 1.028566 3.456645 0.309168 0.064900 0.003755 0.277440 0.162779
Calculating covariance matrix
[====|====|====|====|====|====|====|====|====|====] 0:00:00
→ loading into symengine environment...
→ pruning branches (`if`/`else`) of saem model...
✔ done
→ finding duplicate expressions in saem predOnly model 0...
[====|====|====|====|====|====|====|====|====|====] 0:00:00
→ finding duplicate expressions in saem predOnly model 1...
[====|====|====|====|====|====|====|====|====|====] 0:00:00
→ finding duplicate expressions in saem predOnly model 2...
[====|====|====|====|====|====|====|====|====|====] 0:00:00
→ optimizing duplicate expressions in saem predOnly model 2...
[====|====|====|====|====|====|====|====|====|====] 0:00:00
✔ done
→ Calculating residuals/tables
✔ done
→ compress origData in nlmixr2 object, save 5952
→ compress phiM in nlmixr2 object, save 64632
→ compress parHist in nlmixr2 object, save 10616
→ compress saem0 in nlmixr2 object, save 27536
>
> # }