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Min-Soo Kim's blog

[NLMIXR2] Recording the results of nlmixr2 example code

I am learning popPK. I needed the executable popPK software, and found nlmixr2 ( https://nlmixr2.org/ ).

Since I want to record my learning curve, I will write every steps.

I installed NLMIXR2 on my Windows machine, and ran a sample code below:

library(nlmixr2)
# \donttest{

one.cmt <- function() {
  ini({
    ## You may label each parameter with a comment
    tka <- 0.45 # Ka
    tcl <- log(c(0, 2.7, 100)) # Log Cl
    ## This works with interactive models
    ## You may also label the preceding line with label("label text")
    tv <- 3.45; label("log V")
    ## the label("Label name") works with all models
    eta.ka ~ 0.6
    eta.cl ~ 0.3
    eta.v ~ 0.1
    add.sd <- 0.7
    prop.sd <- 0.01
  })
  model({
    ka <- exp(tka + eta.ka)
    cl <- exp(tcl + eta.cl)
    v <- exp(tv + eta.v)
    linCmt() ~ add(add.sd) + prop(prop.sd)
  })
}

fitF <- nlmixr(one.cmt, theo_sd, "focei")

fitS <- nlmixr(one.cmt, theo_sd, "saem")

# }

 

 

The results was the same as below:

→ optimizing duplicate expressions in EBE model...
[====|====|====|====|====|====|====|====|====|====] 100%; 0:00:00 
→ compiling inner model...
 done
→ finding duplicate expressions in FD model...
[====|====|====|====|====|====|====|====|====|====] 100%; 0:00:00 
→ optimizing duplicate expressions in FD model...
[====|====|====|====|====|====|====|====|====|====] 100%; 0:00:00 
→ compiling EBE model...
 done
→ compiling events FD model...
 done
rxode2 2.0.12 using 10 threads (see ?getRxThreads)
  no cache: create with `rxCreateCache()`
Key: U: Unscaled Parameters; X: Back-transformed parameters; G: Gill difference gradient approximation
F: Forward difference gradient approximation
C: Central difference gradient approximation
M: Mixed forward and central difference gradient approximation
Unscaled parameters for Omegas=chol(solve(omega));
Diagonals are transformed, as specified by foceiControl(diagXform=)
|-----+---------------+-----------+-----------+-----------+-----------|
|    #| Objective Fun |       tka |       tcl |        tv |    add.sd |
|.....................|   prop.sd |        o1 |        o2 |        o3 |
|    1|     133.41448 |   -0.7442 |   -0.4283 |     1.000 |   -0.5988 |
|.....................|    -1.000 |   -0.3452 |   -0.2202 |   0.02807 |
|    U|     133.41448 |    0.4500 |    0.9933 |     3.450 |    0.7000 |
|.....................|   0.01000 |     1.136 |     1.351 |     1.778 |
|    X|     133.41448 |     1.568 |     2.700 |     31.50 |    0.7000 |
|.....................|   0.01000 |     1.136 |     1.351 |     1.778 |
|    G|    Gill Diff. |   -0.9125 |    -1.615 |    -3.070 |     2.435 |
|.....................|   -0.1592 |    -11.82 |    -35.27 |    -34.85 |
|    2|     122.43055 |   -0.7263 |   -0.3968 |     1.060 |   -0.6464 |
|.....................|   -0.9969 |   -0.1141 |    0.4692 |    0.7093 |
|    U|     122.43055 |    0.4678 |     1.025 |     3.510 |    0.6833 |
|.....................|   0.01002 |     1.399 |     2.283 |     2.990 |
|    X|     122.43055 |     1.597 |     2.787 |     33.45 |    0.6833 |
|.....................|   0.01002 |     1.399 |     2.283 |     2.990 |
|    F| Forward Diff. |   -0.9248 |     14.56 |     70.61 |    -6.013 |
|.....................|   -0.2357 |     14.20 |     16.75 |     14.05 |
|    3|     690.37789 |   -0.7041 |   -0.5837 |    0.1046 |   -0.5874 |
|.....................|   -0.9920 |   -0.1913 |    0.5969 |    0.8706 |
|    U|     690.37789 |    0.4901 |    0.8379 |     2.555 |    0.7040 |
|.....................|   0.01004 |     1.311 |     2.455 |     3.276 |
|    X|     690.37789 |     1.633 |     2.311 |     12.87 |    0.7040 |
|.....................|   0.01004 |     1.311 |     2.455 |     3.276 |
|    4|     120.83482 |   -0.7251 |   -0.4157 |    0.9682 |   -0.6386 |
|.....................|   -0.9966 |   -0.1326 |    0.4474 |    0.6911 |
|    U|     120.83482 |    0.4690 |     1.006 |     3.418 |    0.6861 |
|.....................|   0.01002 |     1.378 |     2.253 |     2.957 |
|    X|     120.83482 |     1.598 |     2.734 |     30.51 |    0.6861 |
|.....................|   0.01002 |     1.378 |     2.253 |     2.957 |
|    F| Forward Diff. |     2.642 |    -6.819 |    -53.06 |    -3.749 |
|.....................|   -0.2091 |     13.15 |     15.49 |     9.370 |
|    5|     118.22220 |   -0.7302 |   -0.4140 |     1.019 |   -0.6252 |
|.....................|   -0.9960 |   -0.1753 |    0.3888 |    0.6473 |
|    U|      118.2222 |    0.4640 |     1.008 |     3.469 |    0.6908 |
|.....................|   0.01002 |     1.329 |     2.174 |     2.879 |
|    X|      118.2222 |     1.590 |     2.739 |     32.12 |    0.6908 |
|.....................|   0.01002 |     1.329 |     2.174 |     2.879 |
|    F| Forward Diff. |   0.01765 |   0.03756 |     11.87 |    -1.578 |
|.....................|   -0.1914 |     7.033 |     11.35 |     6.671 |
|    6|     117.74338 |   -0.7307 |   -0.4081 |    0.9753 |   -0.6182 |
|.....................|   -0.9950 |   -0.2134 |    0.3198 |    0.6053 |
|    U|     117.74338 |    0.4635 |     1.013 |     3.425 |    0.6932 |
|.....................|   0.01002 |     1.286 |     2.081 |     2.805 |
|    X|     117.74338 |     1.590 |     2.755 |     30.73 |    0.6932 |
|.....................|   0.01002 |     1.286 |     2.081 |     2.805 |
|    F| Forward Diff. |     1.126 |    -2.103 |    -36.64 |   -0.2032 |
|.....................|   -0.1718 |     3.311 |     7.046 |     4.162 |
|    7|     116.83266 |   -0.7292 |   -0.4104 |     1.027 |   -0.6289 |
|.....................|   -0.9934 |   -0.2199 |    0.2482 |    0.5604 |
|    U|     116.83266 |    0.4650 |     1.011 |     3.477 |    0.6895 |
|.....................|   0.01003 |     1.279 |     1.984 |     2.725 |
|    X|     116.83266 |     1.592 |     2.749 |     32.37 |    0.6895 |
|.....................|   0.01003 |     1.279 |     1.984 |     2.725 |
|    F| Forward Diff. |   -0.2504 |    0.9953 |     17.45 |   -0.8038 |
|.....................|   -0.1904 |     2.235 |     1.806 |     1.747 |
|    8|     116.82421 |   -0.7320 |   -0.4335 |     1.004 |   -0.6308 |
|.....................|   -0.9811 |   -0.2479 |    0.1991 |    0.4857 |
|    U|     116.82421 |    0.4621 |    0.9881 |     3.454 |    0.6888 |
|.....................|   0.01009 |     1.247 |     1.918 |     2.592 |
|    X|     116.82421 |     1.587 |     2.686 |     31.64 |    0.6888 |
|.....................|   0.01009 |     1.247 |     1.918 |     2.592 |
|    F| Forward Diff. |   -0.1447 |    -6.916 |    -6.236 |   -0.5044 |
|.....................|   -0.1786 |   -0.6123 |    -1.937 |    -2.821 |
|    9|     116.82328 |   -0.7312 |   -0.3859 |     1.012 |   -0.6244 |
|.....................|   -0.9762 |   -0.2578 |    0.1953 |    0.4848 |
|    U|     116.82328 |    0.4630 |     1.036 |     3.462 |    0.6910 |
|.....................|   0.01012 |     1.236 |     1.913 |     2.590 |
|    X|     116.82328 |     1.589 |     2.817 |     31.88 |    0.6910 |
|.....................|   0.01012 |     1.236 |     1.913 |     2.590 |
|    F| Forward Diff. |  -0.04912 |     6.546 |     2.755 |    0.3318 |
|.....................|   -0.1750 |    -1.425 |    -2.138 |    -2.844 |
|   10|     116.71967 |   -0.7310 |   -0.4062 |     1.004 |   -0.6255 |
|.....................|   -0.9757 |   -0.2533 |    0.2019 |    0.4936 |
|    U|     116.71967 |    0.4631 |     1.015 |     3.454 |    0.6907 |
|.....................|   0.01012 |     1.241 |     1.922 |     2.606 |
|    X|     116.71967 |     1.589 |     2.760 |     31.61 |    0.6907 |
|.....................|   0.01012 |     1.241 |     1.922 |     2.606 |
|    F| Forward Diff. |   0.05245 |    0.5800 |    -5.549 |   0.03417 |
|.....................|   -0.1793 |    -1.379 |    -1.783 |    -2.382 |
|   11|     116.76081 |   -0.7312 |   -0.4084 |     1.025 |   -0.6256 |
|.....................|   -0.9750 |   -0.2480 |    0.2088 |    0.5028 |
|    U|     116.76081 |    0.4629 |     1.013 |     3.475 |    0.6906 |
|.....................|   0.01013 |     1.247 |     1.931 |     2.622 |
|    X|     116.76081 |     1.589 |     2.754 |     32.30 |    0.6906 |
|.....................|   0.01013 |     1.247 |     1.931 |     2.622 |
|   12|     116.68638 |   -0.7311 |   -0.4071 |     1.012 |   -0.6255 |
|.....................|   -0.9754 |   -0.2512 |    0.2047 |    0.4973 |
|    U|     116.68638 |    0.4631 |     1.015 |     3.462 |    0.6907 |
|.....................|   0.01012 |     1.243 |     1.925 |     2.613 |
|    X|     116.68638 |     1.589 |     2.758 |     31.89 |    0.6907 |
|.....................|   0.01012 |     1.243 |     1.925 |     2.613 |
|    F| Forward Diff. |   -0.1171 |    0.8023 |     1.821 |    0.1466 |
|.....................|   -0.1772 |    -1.209 |    -1.628 |    -2.214 |
|   13|     116.66590 |   -0.7308 |   -0.4093 |     1.007 |   -0.6259 |
|.....................|   -0.9749 |   -0.2479 |    0.2092 |    0.5034 |
|    U|      116.6659 |    0.4634 |     1.012 |     3.457 |    0.6905 |
|.....................|   0.01013 |     1.247 |     1.931 |     2.623 |
|    X|      116.6659 |     1.589 |     2.752 |     31.73 |    0.6905 |
|.....................|   0.01013 |     1.247 |     1.931 |     2.623 |
|    F| Forward Diff. |  0.005624 |  -0.08427 |    -2.657 |   -0.2328 |
|.....................|   -0.1868 |   -0.7794 |    -1.171 |    -1.828 |
|   14|     116.65642 |   -0.7308 |   -0.4091 |     1.015 |   -0.6253 |
|.....................|   -0.9744 |   -0.2457 |    0.2125 |    0.5085 |
|    U|     116.65642 |    0.4634 |     1.013 |     3.465 |    0.6908 |
|.....................|   0.01013 |     1.249 |     1.936 |     2.633 |
|    X|     116.65642 |     1.589 |     2.753 |     31.96 |    0.6908 |
|.....................|   0.01013 |     1.249 |     1.936 |     2.633 |
|    F| Forward Diff. |   -0.1383 |    0.4131 |     4.073 |   0.08716 |
|.....................|   -0.1789 |   -0.5559 |    -1.040 |    -1.502 |
|   15|     116.63997 |   -0.7308 |   -0.4103 |     1.009 |   -0.6224 |
|.....................|   -0.9723 |   -0.2471 |    0.2126 |    0.5156 |
|    U|     116.63997 |    0.4634 |     1.011 |     3.459 |    0.6917 |
|.....................|   0.01014 |     1.248 |     1.936 |     2.645 |
|    X|     116.63997 |     1.589 |     2.749 |     31.78 |    0.6917 |
|.....................|   0.01014 |     1.248 |     1.936 |     2.645 |
|    F| Forward Diff. |  -0.01776 |   -0.2763 |    -1.122 |    0.3482 |
|.....................|   -0.1800 |    -1.153 |   -0.9215 |    -1.219 |
|   16|     116.63122 |   -0.7311 |   -0.4092 |     1.013 |   -0.6250 |
|.....................|   -0.9700 |   -0.2411 |    0.2137 |    0.5215 |
|    U|     116.63122 |    0.4631 |     1.012 |     3.463 |    0.6908 |
|.....................|   0.01015 |     1.254 |     1.938 |     2.656 |
|    X|     116.63122 |     1.589 |     2.752 |     31.90 |    0.6908 |
|.....................|   0.01015 |     1.254 |     1.938 |     2.656 |
|    F| Forward Diff. |  -0.08259 |    0.2523 |     2.418 |  0.001797 |
|.....................|   -0.1813 |  -0.07887 |   -0.8017 |    -1.008 |
|   17|     116.62365 |   -0.7316 |   -0.4097 |     1.009 |   -0.6275 |
|.....................|   -0.9643 |   -0.2434 |    0.2141 |    0.5277 |
|    U|     116.62365 |    0.4626 |     1.012 |     3.459 |    0.6900 |
|.....................|   0.01018 |     1.252 |     1.938 |     2.667 |
|    X|     116.62365 |     1.588 |     2.751 |     31.77 |    0.6900 |
|.....................|   0.01018 |     1.252 |     1.938 |     2.667 |
|    F| Forward Diff. |  -0.02682 |   -0.1560 |    -1.138 |   -0.1936 |
|.....................|   -0.1836 |   -0.2595 |   -0.6058 |   -0.7101 |
|   18|     116.62110 |   -0.7313 |   -0.4099 |     1.012 |   -0.6243 |
|.....................|   -0.9598 |   -0.2474 |    0.2179 |    0.5331 |
|    U|      116.6211 |    0.4629 |     1.012 |     3.462 |    0.6911 |
|.....................|   0.01020 |     1.247 |     1.943 |     2.676 |
|    X|      116.6211 |     1.589 |     2.750 |     31.87 |    0.6911 |
|.....................|   0.01020 |     1.247 |     1.943 |     2.676 |
|    F| Forward Diff. |  -0.08317 |  -0.03138 |     1.785 |    0.4059 |
|.....................|   -0.1634 |    -1.291 |   -0.3853 |   -0.3083 |
|   19|     116.61622 |   -0.7304 |   -0.4100 |     1.009 |   -0.6209 |
|.....................|   -0.9534 |   -0.2412 |    0.2189 |    0.5329 |
|    U|     116.61622 |    0.4638 |     1.012 |     3.459 |    0.6923 |
|.....................|   0.01023 |     1.254 |     1.945 |     2.676 |
|    X|     116.61622 |     1.590 |     2.750 |     31.79 |    0.6923 |
|.....................|   0.01023 |     1.254 |     1.945 |     2.676 |
|    F| Forward Diff. |   0.03574 |   -0.1737 |   -0.5811 |    0.6410 |
|.....................|   -0.1769 |   -0.3995 |   -0.2483 |   -0.4417 |
|   20|     116.62087 |   -0.7307 |   -0.4085 |     1.014 |   -0.6273 |
|.....................|   -0.9505 |   -0.2377 |    0.2207 |    0.5365 |
|    U|     116.62087 |    0.4634 |     1.013 |     3.464 |    0.6900 |
|.....................|   0.01025 |     1.258 |     1.947 |     2.682 |
|    X|     116.62087 |     1.590 |     2.754 |     31.93 |    0.6900 |
|.....................|   0.01025 |     1.258 |     1.947 |     2.682 |
|   21|     116.61504 |   -0.7305 |   -0.4094 |     1.011 |   -0.6229 |
|.....................|   -0.9528 |   -0.2399 |    0.2197 |    0.5343 |
|    U|     116.61504 |    0.4637 |     1.012 |     3.461 |    0.6916 |
|.....................|   0.01024 |     1.256 |     1.946 |     2.678 |
|    X|     116.61504 |     1.590 |     2.752 |     31.85 |    0.6916 |
|.....................|   0.01024 |     1.256 |     1.946 |     2.678 |
|    F| Forward Diff. | -0.005380 |   0.09139 |     1.199 |    0.3548 |
|.....................|   -0.1630 |   -0.3128 |   -0.1618 |   -0.3263 |
|   22|     116.61423 |   -0.7306 |   -0.4095 |     1.009 |   -0.6248 |
|.....................|   -0.9513 |   -0.2394 |    0.2198 |    0.5352 |
|    U|     116.61423 |    0.4635 |     1.012 |     3.459 |    0.6909 |
|.....................|   0.01024 |     1.256 |     1.946 |     2.680 |
|    X|     116.61423 |     1.590 |     2.751 |     31.78 |    0.6909 |
|.....................|   0.01024 |     1.256 |     1.946 |     2.680 |
|    F| Forward Diff. |   0.04298 |  -0.07197 |   -0.9845 |   -0.1362 |
|.....................|   -0.1840 |   0.09766 |   -0.2390 |   -0.3173 |
|   23|     116.61284 |   -0.7312 |   -0.4094 |     1.010 |   -0.6250 |
|.....................|   -0.9482 |   -0.2397 |    0.2199 |    0.5360 |
|    U|     116.61284 |    0.4630 |     1.012 |     3.460 |    0.6909 |
|.....................|   0.01026 |     1.256 |     1.946 |     2.682 |
|    X|     116.61284 |     1.589 |     2.752 |     31.82 |    0.6909 |
|.....................|   0.01026 |     1.256 |     1.946 |     2.682 |
|    F| Forward Diff. |  -0.01562 |   0.03946 |    0.2731 |   -0.1531 |
|.....................|   -0.1815 |   0.07943 |   -0.1421 |   -0.2798 |
|   24|     116.61232 |   -0.7312 |   -0.4095 |     1.009 |   -0.6239 |
|.....................|   -0.9455 |   -0.2399 |    0.2201 |    0.5375 |
|    U|     116.61232 |    0.4630 |     1.012 |     3.459 |    0.6912 |
|.....................|   0.01027 |     1.256 |     1.946 |     2.684 |
|    X|     116.61232 |     1.589 |     2.751 |     31.79 |    0.6912 |
|.....................|   0.01027 |     1.256 |     1.946 |     2.684 |
|    F| Forward Diff. |  0.007006 |  -0.06359 |   -0.5821 |   0.09673 |
|.....................|   -0.1769 |    0.1113 |   -0.1188 |   -0.2030 |
|   25|     116.61137 |   -0.7306 |   -0.4094 |     1.010 |   -0.6243 |
|.....................|   -0.9423 |   -0.2404 |    0.2201 |    0.5384 |
|    U|     116.61137 |    0.4636 |     1.012 |     3.460 |    0.6911 |
|.....................|   0.01029 |     1.255 |     1.946 |     2.686 |
|    X|     116.61137 |     1.590 |     2.752 |     31.82 |    0.6911 |
|.....................|   0.01029 |     1.255 |     1.946 |     2.686 |
|    F| Forward Diff. |   0.01818 |   0.04403 |    0.3297 |    0.2253 |
|.....................|   -0.1810 |   -0.3784 |  -0.07828 |   -0.1537 |
|   26|     116.61067 |   -0.7307 |   -0.4094 |     1.010 |   -0.6252 |
|.....................|   -0.9391 |   -0.2398 |    0.2200 |    0.5389 |
|    U|     116.61067 |    0.4635 |     1.012 |     3.460 |    0.6908 |
|.....................|   0.01030 |     1.256 |     1.946 |     2.687 |
|    X|     116.61067 |     1.590 |     2.752 |     31.81 |    0.6908 |
|.....................|   0.01030 |     1.256 |     1.946 |     2.687 |
|    F| Forward Diff. |   0.02236 |   0.02048 |  0.008892 |    0.1135 |
|.....................|   -0.1799 |   -0.3013 |  -0.07552 |   -0.1386 |
|   27|     116.61200 |   -0.7311 |   -0.4097 |     1.010 |   -0.6271 |
|.....................|   -0.9359 |   -0.2346 |    0.2213 |    0.5413 |
|    U|       116.612 |    0.4631 |     1.012 |     3.460 |    0.6901 |
|.....................|   0.01032 |     1.262 |     1.948 |     2.691 |
|    X|       116.612 |     1.589 |     2.751 |     31.80 |    0.6901 |
|.....................|   0.01032 |     1.262 |     1.948 |     2.691 |
|   28|     116.61064 |   -0.7308 |   -0.4095 |     1.010 |   -0.6258 |
|.....................|   -0.9380 |   -0.2381 |    0.2205 |    0.5397 |
|    U|     116.61064 |    0.4634 |     1.012 |     3.460 |    0.6906 |
|.....................|   0.01031 |     1.258 |     1.947 |     2.688 |
|    X|     116.61064 |     1.589 |     2.751 |     31.80 |    0.6906 |
|.....................|   0.01031 |     1.258 |     1.947 |     2.688 |
|    F| Forward Diff. |   0.02159 |  -0.01782 |  -0.03858 |   0.09486 |
|.....................|   -0.1871 |   -0.1276 |   -0.1289 |  -0.04090 |
|   29|     116.61059 |   -0.7309 |   -0.4094 |     1.010 |   -0.6262 |
|.....................|   -0.9372 |   -0.2375 |    0.2210 |    0.5399 |
|    U|     116.61059 |    0.4633 |     1.012 |     3.460 |    0.6904 |
|.....................|   0.01031 |     1.259 |     1.947 |     2.688 |
|    X|     116.61059 |     1.589 |     2.752 |     31.81 |    0.6904 |
|.....................|   0.01031 |     1.259 |     1.947 |     2.688 |
|    C| Central Diff. |  0.001346 |  -0.03041 |   0.02816 |   -0.1573 |
|.....................|   -0.1911 |    0.1540 |   -0.1089 |  -0.05880 |
|   30|     116.61019 |   -0.7309 |   -0.4093 |     1.010 |   -0.6257 |
|.....................|   -0.9364 |   -0.2380 |    0.2213 |    0.5401 |
|    U|     116.61019 |    0.4633 |     1.012 |     3.460 |    0.6906 |
|.....................|   0.01032 |     1.258 |     1.948 |     2.689 |
|    X|     116.61019 |     1.589 |     2.752 |     31.81 |    0.6906 |
|.....................|   0.01032 |     1.258 |     1.948 |     2.689 |
|   31|     116.60950 |   -0.7311 |   -0.4092 |     1.010 |   -0.6255 |
|.....................|   -0.9325 |   -0.2378 |    0.2209 |    0.5400 |
|    U|      116.6095 |    0.4631 |     1.012 |     3.460 |    0.6907 |
|.....................|   0.01034 |     1.258 |     1.947 |     2.689 |
|    X|      116.6095 |     1.589 |     2.752 |     31.81 |    0.6907 |
|.....................|   0.01034 |     1.258 |     1.947 |     2.689 |
|   32|     116.60794 |   -0.7318 |   -0.4089 |     1.011 |   -0.6249 |
|.....................|   -0.9184 |   -0.2368 |    0.2194 |    0.5399 |
|    U|     116.60794 |    0.4623 |     1.013 |     3.461 |    0.6909 |
|.....................|   0.01041 |     1.259 |     1.945 |     2.688 |
|    X|     116.60794 |     1.588 |     2.753 |     31.83 |    0.6909 |
|.....................|   0.01041 |     1.259 |     1.945 |     2.688 |
|   33|     116.60696 |   -0.7328 |   -0.4084 |     1.011 |   -0.6240 |
|.....................|   -0.8992 |   -0.2355 |    0.2173 |    0.5397 |
|    U|     116.60696 |    0.4614 |     1.013 |     3.461 |    0.6912 |
|.....................|   0.01050 |     1.261 |     1.942 |     2.688 |
|    X|     116.60696 |     1.586 |     2.754 |     31.86 |    0.6912 |
|.....................|   0.01050 |     1.261 |     1.942 |     2.688 |
|    F| Forward Diff. |   -0.1153 |    0.3832 |     1.748 |  -0.04713 |
|.....................|   -0.1874 |    0.5267 |   -0.3414 |  -0.07396 |
|   34|     116.59964 |   -0.7323 |   -0.4093 |     1.009 |   -0.6220 |
|.....................|   -0.8612 |   -0.2345 |    0.2187 |    0.5363 |
|    U|     116.59964 |    0.4619 |     1.012 |     3.459 |    0.6919 |
|.....................|   0.01069 |     1.262 |     1.944 |     2.682 |
|    X|     116.59964 |     1.587 |     2.752 |     31.79 |    0.6919 |
|.....................|   0.01069 |     1.262 |     1.944 |     2.682 |
|    F| Forward Diff. |  -0.03304 |  0.003257 |   -0.6570 |    0.2631 |
|.....................|   -0.1864 |    0.6584 |   -0.3035 |   -0.3335 |
|   35|     116.59051 |   -0.7291 |   -0.4098 |     1.010 |   -0.6234 |
|.....................|   -0.8230 |   -0.2363 |    0.2186 |    0.5375 |
|    U|     116.59051 |    0.4651 |     1.012 |     3.460 |    0.6914 |
|.....................|   0.01088 |     1.260 |     1.944 |     2.684 |
|    X|     116.59051 |     1.592 |     2.750 |     31.82 |    0.6914 |
|.....................|   0.01088 |     1.260 |     1.944 |     2.684 |
|   36|     116.57162 |   -0.7198 |   -0.4115 |     1.009 |   -0.6260 |
|.....................|   -0.7083 |   -0.2375 |    0.2163 |    0.5389 |
|    U|     116.57162 |    0.4744 |     1.010 |     3.459 |    0.6905 |
|.....................|   0.01146 |     1.259 |     1.941 |     2.687 |
|    X|     116.57162 |     1.607 |     2.746 |     31.79 |    0.6905 |
|.....................|   0.01146 |     1.259 |     1.941 |     2.687 |
|   37|     116.54812 |   -0.6848 |   -0.4177 |     1.008 |   -0.6365 |
|.....................|   -0.2789 |   -0.2441 |    0.2084 |    0.5452 |
|    U|     116.54812 |    0.5094 |     1.004 |     3.458 |    0.6868 |
|.....................|   0.01361 |     1.251 |     1.930 |     2.698 |
|    X|     116.54812 |     1.664 |     2.729 |     31.75 |    0.6868 |
|.....................|   0.01361 |     1.251 |     1.930 |     2.698 |
|    F| Forward Diff. |     2.536 |    -2.301 |    -2.967 |   -0.5818 |
|.....................|   -0.2397 |  -0.09478 |   -0.7963 |   0.07297 |
|   38|     116.39163 |   -0.6924 |   -0.4203 |     1.011 |   -0.6467 |
|.....................|    0.3056 |   -0.2534 |    0.2038 |    0.5484 |
|    U|     116.39163 |    0.5018 |     1.001 |     3.461 |    0.6832 |
|.....................|   0.01653 |     1.241 |     1.924 |     2.704 |
|    X|     116.39163 |     1.652 |     2.722 |     31.83 |    0.6832 |
|.....................|   0.01653 |     1.241 |     1.924 |     2.704 |
|   39|     116.03517 |   -0.7015 |   -0.4408 |     1.002 |   -0.6806 |
|.....................|     2.059 |   -0.2820 |    0.1858 |    0.5584 |
|    U|     116.03517 |    0.4927 |    0.9808 |     3.452 |    0.6714 |
|.....................|   0.02529 |     1.208 |     1.900 |     2.721 |
|    X|     116.03517 |     1.637 |     2.667 |     31.57 |    0.6714 |
|.....................|   0.02529 |     1.208 |     1.900 |     2.721 |
|   40|     116.26977 |   -0.7431 |   -0.5179 |    0.9754 |   -0.8151 |
|.....................|     9.072 |   -0.3961 |    0.1154 |    0.5982 |
|    U|     116.26977 |    0.4511 |    0.9037 |     3.425 |    0.6243 |
|.....................|   0.06036 |     1.078 |     1.805 |     2.792 |
|    X|     116.26977 |     1.570 |     2.469 |     30.73 |    0.6243 |
|.....................|   0.06036 |     1.078 |     1.805 |     2.792 |
|    F| Forward Diff. |     1.479 |    -9.068 |    -8.967 |   -0.1062 |
|.....................|   -0.4299 |    -4.938 |    -1.944 |    0.5378 |
|   41|     116.43852 |   -0.7628 |   -0.5280 |    0.9829 |   -0.8546 |
|.....................|     11.41 |   -0.4290 |   0.09762 |    0.6078 |
|    U|     116.43852 |    0.4313 |    0.8936 |     3.433 |    0.6105 |
|.....................|   0.07205 |     1.041 |     1.781 |     2.809 |
|    X|     116.43852 |     1.539 |     2.444 |     30.97 |    0.6105 |
|.....................|   0.07205 |     1.041 |     1.781 |     2.809 |
|   42|     115.23898 |   -0.7277 |   -0.4761 |    0.9956 |   -0.7541 |
|.....................|     6.012 |   -0.3433 |    0.1489 |    0.5792 |
|    U|     115.23898 |    0.4665 |    0.9455 |     3.446 |    0.6456 |
|.....................|   0.04506 |     1.138 |     1.850 |     2.758 |
|    X|     115.23898 |     1.594 |     2.574 |     31.36 |    0.6456 |
|.....................|   0.04506 |     1.138 |     1.850 |     2.758 |
|    F| Forward Diff. |    0.3734 |    -17.80 |    -16.93 |     4.401 |
|.....................|   -0.4572 |    -12.94 |    -3.125 |     1.012 |
|   43|     113.95191 |   -0.7589 |   -0.4500 |     1.047 |   -0.8372 |
|.....................|     9.964 |   -0.3651 |    0.1234 |    0.5971 |
|    U|     113.95191 |    0.4353 |    0.9716 |     3.497 |    0.6166 |
|.....................|   0.06482 |     1.114 |     1.815 |     2.790 |
|    X|     113.95191 |     1.545 |     2.642 |     33.03 |    0.6166 |
|.....................|   0.06482 |     1.114 |     1.815 |     2.790 |
|    F| Forward Diff. |    -1.276 |    -8.477 |     36.59 |     9.955 |
|.....................|   -0.1865 |    -16.24 |    -6.216 |     2.736 |
|   44|     114.11080 |   -0.8130 |   -0.3803 |     1.001 |   -0.9868 |
|.....................|     13.91 |   -0.4622 |   0.08739 |    0.7195 |
|    U|      114.1108 |    0.3812 |     1.041 |     3.451 |    0.5642 |
|.....................|   0.08456 |     1.003 |     1.767 |     3.008 |
|    X|      114.1108 |     1.464 |     2.833 |     31.53 |    0.5642 |
|.....................|   0.08456 |     1.003 |     1.767 |     3.008 |
|   45|     112.99333 |   -0.7836 |   -0.4136 |     1.009 |   -0.9116 |
|.....................|     11.81 |   -0.4032 |    0.1093 |    0.6531 |
|    U|     112.99333 |    0.4106 |     1.008 |     3.459 |    0.5905 |
|.....................|   0.07405 |     1.070 |     1.796 |     2.890 |
|    X|     112.99333 |     1.508 |     2.740 |     31.79 |    0.5905 |
|.....................|   0.07405 |     1.070 |     1.796 |     2.890 |
|    F| Forward Diff. |    -1.067 |    -2.224 |    0.4394 |     11.10 |
|.....................|  -0.05293 |    -21.20 |    -7.216 |     2.396 |
|   46|     111.42492 |   -0.7683 |   -0.3637 |     1.002 |   -0.9523 |
|.....................|     9.968 |   -0.2602 |    0.1684 |    0.6459 |
|    U|     111.42492 |    0.4259 |     1.058 |     3.452 |    0.5763 |
|.....................|   0.06484 |     1.233 |     1.876 |     2.877 |
|    X|     111.42492 |     1.531 |     2.880 |     31.57 |    0.5763 |
|.....................|   0.06484 |     1.233 |     1.876 |     2.877 |
|    F| Forward Diff. |   -0.4560 |     10.43 |    -4.213 |     2.017 |
|.....................|   -0.5728 |    -3.133 |    -2.337 |     2.918 |
|   47|     110.22906 |   -0.7724 |   -0.4408 |     1.022 |    -1.016 |
|.....................|     11.81 |   -0.2012 |    0.1898 |    0.6174 |
|    U|     110.22906 |    0.4218 |    0.9807 |     3.472 |    0.5540 |
|.....................|   0.07407 |     1.300 |     1.905 |     2.826 |
|    X|     110.22906 |     1.525 |     2.666 |     32.21 |    0.5540 |
|.....................|   0.07407 |     1.300 |     1.905 |     2.826 |
|    F| Forward Diff. |    -1.208 |    -9.400 |     12.06 |     3.953 |
|.....................|   -0.4291 |     3.676 |    -1.474 |     2.209 |
|   48|     109.28496 |   -0.7787 |   -0.4131 |    0.9910 |    -1.082 |
|.....................|     13.66 |   -0.1851 |    0.1944 |    0.6126 |
|    U|     109.28496 |    0.4155 |     1.008 |     3.441 |    0.5307 |
|.....................|   0.08331 |     1.318 |     1.911 |     2.818 |
|    X|     109.28496 |     1.515 |     2.741 |     31.22 |    0.5307 |
|.....................|   0.08331 |     1.318 |     1.911 |     2.818 |
|    F| Forward Diff. |  -0.02901 |    -3.661 |    -20.35 |     6.346 |
|.....................|   -0.2249 |     5.731 |    -1.589 |     1.201 |
|   49|     108.10870 |   -0.7878 |   -0.3964 |     1.013 |    -1.175 |
|.....................|     15.51 |   -0.1898 |    0.1945 |    0.6146 |
|    U|      108.1087 |    0.4063 |     1.025 |     3.463 |    0.4983 |
|.....................|   0.09255 |     1.313 |     1.912 |     2.821 |
|    X|      108.1087 |     1.501 |     2.788 |     31.92 |    0.4983 |
|.....................|   0.09255 |     1.313 |     1.912 |     2.821 |
|   50|     107.37184 |   -0.7981 |   -0.3832 |     1.008 |    -1.270 |
|.....................|     17.58 |   -0.1865 |    0.1923 |    0.6187 |
|    U|     107.37184 |    0.3961 |     1.038 |     3.458 |    0.4653 |
|.....................|    0.1029 |     1.317 |     1.909 |     2.829 |
|    X|     107.37184 |     1.486 |     2.825 |     31.75 |    0.4653 |
|.....................|    0.1029 |     1.317 |     1.909 |     2.829 |
|   51|     106.69485 |   -0.8190 |   -0.3520 |     1.020 |    -1.469 |
|.....................|     21.81 |   -0.1862 |    0.1895 |    0.6258 |
|    U|     106.69485 |    0.3752 |     1.070 |     3.470 |    0.3953 |
|.....................|    0.1241 |     1.317 |     1.905 |     2.841 |
|    X|     106.69485 |     1.455 |     2.914 |     32.12 |    0.3953 |
|.....................|    0.1241 |     1.317 |     1.905 |     2.841 |
|    F| Forward Diff. |    -1.527 |     13.18 |     7.260 |     11.59 |
|.....................|    0.4292 |     4.108 |    -2.364 |   -0.1560 |
|   52|     105.34635 |   -0.7597 |   -0.3437 |     1.014 |    -1.772 |
|.....................|     23.81 |   -0.3009 |    0.2573 |    0.5106 |
|    U|     105.34635 |    0.4345 |     1.078 |     3.464 |    0.2892 |
|.....................|    0.1340 |     1.187 |     1.996 |     2.636 |
|    X|     105.34635 |     1.544 |     2.938 |     31.95 |    0.2892 |
|.....................|    0.1340 |     1.187 |     1.996 |     2.636 |
|    F| Forward Diff. |     1.694 |     18.33 |    -1.820 |     3.258 |
|.....................|    0.1785 |    -7.542 |     1.531 |    -3.438 |
|   53|     104.92085 |   -0.7434 |   -0.4288 |     1.020 |    -1.865 |
|.....................|     25.42 |   -0.2333 |    0.2809 |    0.5787 |
|    U|     104.92085 |    0.4508 |    0.9928 |     3.470 |    0.2569 |
|.....................|    0.1421 |     1.263 |     2.028 |     2.757 |
|    X|     104.92085 |     1.570 |     2.699 |     32.14 |    0.2569 |
|.....................|    0.1421 |     1.263 |     2.028 |     2.757 |
|    F| Forward Diff. |     3.300 |    -11.88 |   -0.5184 |    0.2361 |
|.....................|    0.3384 |    0.2167 |     2.310 |    -1.630 |
|   54|     104.80225 |   -0.7764 |   -0.4112 |     1.017 |    -1.686 |
|.....................|     21.67 |   -0.2260 |    0.2293 |    0.6712 |
|    U|     104.80225 |    0.4178 |     1.010 |     3.467 |    0.3195 |
|.....................|    0.1234 |     1.272 |     1.959 |     2.922 |
|    X|     104.80225 |     1.519 |     2.747 |     32.05 |    0.3195 |
|.....................|    0.1234 |     1.272 |     1.959 |     2.922 |
|    F| Forward Diff. |     1.108 |    -3.779 |     3.916 |     1.067 |
|.....................|   -0.2337 |    0.7778 |   -0.3866 |     2.205 |
|   55|     104.38543 |   -0.7999 |   -0.3814 |     1.016 |    -1.805 |
|.....................|     23.77 |   -0.2337 |    0.2229 |    0.6246 |
|    U|     104.38543 |    0.3943 |     1.040 |     3.466 |    0.2778 |
|.....................|    0.1339 |     1.263 |     1.950 |     2.839 |
|    X|     104.38543 |     1.483 |     2.830 |       32. |    0.2778 |
|.....................|    0.1339 |     1.263 |     1.950 |     2.839 |
|    F| Forward Diff. |    0.1824 |     5.009 |    0.3600 |    0.3865 |
|.....................|   0.02636 |   -0.2279 |    -1.600 |    0.1688 |
|   56|     104.32981 |   -0.8016 |   -0.3985 |     1.015 |    -1.805 |
|.....................|     23.74 |   -0.2350 |    0.2589 |    0.6049 |
|    U|     104.32981 |    0.3926 |     1.023 |     3.465 |    0.2779 |
|.....................|    0.1337 |     1.261 |     1.999 |     2.804 |
|    X|     104.32981 |     1.481 |     2.782 |     31.98 |    0.2779 |
|.....................|    0.1337 |     1.261 |     1.999 |     2.804 |
|    F| Forward Diff. |   0.04270 |   -0.4550 |   -0.4399 |    0.5042 |
|.....................|   0.02903 |   -0.3006 |    0.8144 |   -0.2880 |
|   57|     104.32320 |   -0.8002 |   -0.3975 |     1.016 |    -1.810 |
|.....................|     23.69 |   -0.2323 |    0.2456 |    0.6126 |
|    U|      104.3232 |    0.3940 |     1.024 |     3.466 |    0.2761 |
|.....................|    0.1334 |     1.264 |     1.981 |     2.818 |
|    X|      104.3232 |     1.483 |     2.784 |     32.00 |    0.2761 |
|.....................|    0.1334 |     1.264 |     1.981 |     2.818 |
|    F| Forward Diff. |    0.1205 |  -0.06260 |    0.2483 |   -0.1176 |
|.....................| -0.005486 | -0.001306 |   -0.1080 |  -0.04867 |
|   58|     104.32320 |   -0.8002 |   -0.3975 |     1.016 |    -1.810 |
|.....................|     23.69 |   -0.2323 |    0.2456 |    0.6126 |
|    U|      104.3232 |    0.3940 |     1.024 |     3.466 |    0.2761 |
|.....................|    0.1334 |     1.264 |     1.981 |     2.818 |
|    X|      104.3232 |     1.483 |     2.784 |     32.00 |    0.2761 |
|.....................|    0.1334 |     1.264 |     1.981 |     2.818 |
calculating covariance matrix
[====|====|====|====|====|====|====|====|====|====] 0:00:00 
done
→ Calculating residuals/tables
 done
→ compress origData in nlmixr2 object, save 5952
→ compress parHist in nlmixr2 object, save 2824
> 
> fitS <- nlmixr(one.cmt, theo_sd, "saem")
 parameter labels from comments will be replaced by 'label()'
→ loading into symengine environment...
→ pruning branches (`if`/`else`) of saem model...
 done
→ finding duplicate expressions in saem model...
[====|====|====|====|====|====|====|====|====|====] 0:00:00 

 done
params:	tka	tcl	tv	V(eta.ka)	V(eta.cl)	V(eta.v)	add.sd	prop.sd
001: -0.080200	1.234448	3.580855	0.570000	0.322404	0.095000	2.465336	0.000111	
002: 0.155871	1.166409	3.532752	0.541500	0.306284	0.090250	1.756233	0.000167	
003: 0.393590	1.008472	3.474704	0.514425	0.290970	0.085737	0.834665	0.132042	
004: 0.432322	0.973484	3.504374	0.488704	0.276421	0.081451	0.497621	0.172408	
005: 0.532176	0.973719	3.506813	0.464269	0.262600	0.077378	0.341588	0.189561	
006: 0.448131	1.014924	3.493418	0.441055	0.249470	0.073509	0.349916	0.160486	
007: 0.407119	1.010794	3.484830	0.419002	0.236997	0.069834	0.288568	0.174087	
008: 0.381553	0.989530	3.458048	0.398052	0.225147	0.066342	0.328027	0.160502	
009: 0.363303	0.975426	3.468222	0.378150	0.213890	0.063025	0.315780	0.156026	
010: 0.337004	1.019006	3.444429	0.359242	0.203195	0.059874	0.349065	0.147588	
011: 0.420793	0.993875	3.461077	0.341280	0.193035	0.056880	0.304890	0.163691	
012: 0.383775	0.996212	3.437767	0.324216	0.183384	0.054036	0.413778	0.135545	
013: 0.335689	1.016572	3.438223	0.308005	0.174214	0.051334	0.328558	0.155219	
014: 0.357823	0.992314	3.443296	0.305527	0.165504	0.048767	0.315997	0.157115	
015: 0.382049	1.020540	3.451679	0.290251	0.157229	0.046329	0.278976	0.157087	
016: 0.385127	1.035558	3.470487	0.275738	0.149367	0.044013	0.284319	0.158505	
017: 0.381571	1.018722	3.473795	0.261952	0.141899	0.041812	0.308665	0.153730	
018: 0.441336	0.994202	3.484597	0.286593	0.134804	0.039721	0.293638	0.141668	
019: 0.404171	0.996810	3.483635	0.311929	0.128064	0.037735	0.298845	0.144124	
020: 0.415838	1.014337	3.476448	0.368027	0.121660	0.035849	0.301057	0.148849	
021: 0.402484	1.015811	3.481952	0.358848	0.115577	0.034056	0.292638	0.150243	
022: 0.391277	1.022718	3.489560	0.387839	0.109799	0.032353	0.293342	0.148476	
023: 0.508820	1.006878	3.497896	0.368447	0.104309	0.030736	0.301778	0.163374	
024: 0.522605	1.024869	3.514102	0.350025	0.099093	0.029199	0.265107	0.166066	
025: 0.490382	0.985421	3.507743	0.338200	0.094139	0.027739	0.282963	0.156156	
026: 0.459087	1.025160	3.484027	0.343572	0.089432	0.026352	0.280383	0.157265	
027: 0.396806	1.036532	3.470643	0.339124	0.084960	0.025034	0.287338	0.159896	
028: 0.489037	0.999253	3.494059	0.322168	0.080712	0.023783	0.253138	0.156688	
029: 0.498914	1.019650	3.474236	0.314876	0.076676	0.022594	0.347971	0.147454	
030: 0.499508	1.015395	3.476929	0.349038	0.072843	0.021464	0.385760	0.146733	
031: 0.407032	1.019296	3.481322	0.331586	0.069200	0.020391	0.270187	0.166484	
032: 0.363138	1.008502	3.487945	0.315007	0.073880	0.019371	0.272866	0.158645	
033: 0.403107	1.022812	3.481947	0.339358	0.070186	0.018403	0.256919	0.159488	
034: 0.403277	1.031133	3.467922	0.367441	0.066676	0.017482	0.273260	0.153151	
035: 0.356988	1.040711	3.463397	0.357645	0.063343	0.016608	0.267510	0.152096	
036: 0.368753	1.022707	3.456159	0.339763	0.065359	0.015778	0.263698	0.159446	
037: 0.353529	1.039461	3.459146	0.322775	0.065295	0.015757	0.323394	0.154857	
038: 0.442326	1.023968	3.454390	0.354803	0.073849	0.014969	0.304630	0.151745	
039: 0.445636	1.000566	3.480692	0.337063	0.070157	0.014220	0.263084	0.154606	
040: 0.424053	0.998035	3.497009	0.341354	0.069939	0.013509	0.268253	0.159598	
041: 0.378205	1.004284	3.492132	0.324287	0.066442	0.012834	0.269847	0.162117	
042: 0.485735	0.996791	3.486485	0.384838	0.081145	0.012192	0.284632	0.153656	
043: 0.387425	1.020300	3.469442	0.365596	0.077088	0.011583	0.294760	0.156750	
044: 0.391308	1.030139	3.471357	0.347316	0.073233	0.011003	0.238619	0.161454	
045: 0.413464	1.048462	3.467858	0.329950	0.069572	0.010453	0.296420	0.151770	
046: 0.444986	1.020124	3.470669	0.348369	0.086979	0.009931	0.293734	0.153624	
047: 0.437550	1.041527	3.456832	0.330951	0.082630	0.009434	0.279501	0.156401	
048: 0.412384	1.023153	3.456453	0.325195	0.078499	0.008962	0.289614	0.151235	
049: 0.365791	1.022745	3.465730	0.308935	0.074574	0.008514	0.244776	0.165255	
050: 0.450867	0.999274	3.474666	0.293488	0.082317	0.008089	0.249341	0.174723	
051: 0.434408	1.021848	3.466336	0.417156	0.081667	0.007684	0.261411	0.167196	
052: 0.409713	1.018364	3.459585	0.396299	0.077584	0.007300	0.273692	0.159768	
053: 0.452405	1.011674	3.471421	0.395850	0.073704	0.006935	0.246243	0.165660	
054: 0.341767	1.016561	3.468694	0.399581	0.070019	0.006588	0.247898	0.168731	
055: 0.368326	1.004881	3.469820	0.379601	0.066518	0.006259	0.239317	0.167094	
056: 0.424987	1.004167	3.475780	0.360621	0.063192	0.006849	0.254220	0.163547	
057: 0.400706	1.001019	3.492452	0.342590	0.063728	0.006506	0.237459	0.178385	
058: 0.381804	1.002612	3.480131	0.328520	0.065239	0.006181	0.230982	0.166438	
059: 0.415528	0.977369	3.474114	0.377385	0.079556	0.005872	0.257225	0.166862	
060: 0.388652	0.989912	3.485805	0.393311	0.075578	0.006082	0.262712	0.172613	
061: 0.456043	0.992509	3.484497	0.393077	0.071799	0.005912	0.277544	0.168302	
062: 0.435333	1.026457	3.483141	0.373423	0.068209	0.006222	0.258587	0.173435	
063: 0.462577	1.033468	3.475715	0.354752	0.084834	0.006529	0.297976	0.169636	
064: 0.436649	1.025558	3.475024	0.347730	0.080593	0.006720	0.275017	0.152158	
065: 0.427589	0.992274	3.460733	0.330343	0.076563	0.006384	0.272691	0.149834	
066: 0.397307	1.031229	3.462192	0.313826	0.078617	0.007355	0.289555	0.142347	
067: 0.383592	1.017982	3.457181	0.298135	0.074686	0.008658	0.256521	0.149924	
068: 0.365475	1.012708	3.466301	0.284598	0.070951	0.008393	0.248230	0.169235	
069: 0.368287	1.026489	3.461986	0.323666	0.070226	0.009215	0.273257	0.178218	
070: 0.359712	1.016197	3.471960	0.345418	0.066714	0.008755	0.251484	0.172162	
071: 0.371980	1.024975	3.464015	0.328147	0.063379	0.008317	0.258341	0.177765	
072: 0.327993	1.004304	3.444457	0.311740	0.069739	0.007901	0.262495	0.164002	
073: 0.409018	1.028198	3.471433	0.296153	0.070332	0.007506	0.270828	0.163620	
074: 0.381015	1.003630	3.482971	0.285298	0.066815	0.007131	0.271372	0.168599	
075: 0.436226	0.989450	3.507681	0.290109	0.087494	0.006774	0.244017	0.170677	
076: 0.456478	1.024767	3.504780	0.275603	0.083119	0.006435	0.256026	0.167087	
077: 0.498002	0.993457	3.500075	0.261823	0.078963	0.006114	0.293664	0.155784	
078: 0.471491	0.994674	3.504558	0.298514	0.075015	0.005808	0.264593	0.166161	
079: 0.495096	1.006077	3.520270	0.365493	0.071745	0.006089	0.240729	0.183161	
080: 0.492989	1.015305	3.511031	0.347218	0.068158	0.006707	0.260197	0.180285	
081: 0.479699	1.010491	3.511448	0.329857	0.067895	0.009134	0.255014	0.172428	
082: 0.482646	0.982529	3.528616	0.321585	0.064500	0.011273	0.239416	0.173642	
083: 0.492686	1.010793	3.516467	0.305506	0.070469	0.010709	0.249879	0.168040	
084: 0.439794	1.035790	3.502281	0.290231	0.066946	0.010668	0.260129	0.169723	
085: 0.485595	1.019877	3.525881	0.339669	0.063598	0.010134	0.253871	0.182322	
086: 0.439234	1.012879	3.520300	0.322686	0.060418	0.009817	0.262724	0.170992	
087: 0.429011	1.008374	3.498176	0.306551	0.057397	0.009326	0.261587	0.172534	
088: 0.384407	1.002324	3.492044	0.316934	0.060285	0.011597	0.283676	0.166441	
089: 0.403636	1.018073	3.482384	0.301087	0.057271	0.011386	0.240434	0.170610	
090: 0.336065	1.020473	3.471586	0.286033	0.054407	0.010817	0.265818	0.170456	
091: 0.341131	1.003554	3.448622	0.271731	0.055658	0.010276	0.357641	0.147777	
092: 0.345032	1.029713	3.449917	0.310566	0.067517	0.009762	0.299167	0.153140	
093: 0.325148	1.025246	3.444557	0.295038	0.064141	0.009274	0.269380	0.154724	
094: 0.330734	1.044315	3.435450	0.280286	0.070752	0.008810	0.266642	0.159033	
095: 0.363003	1.048239	3.457472	0.404852	0.068836	0.008370	0.249814	0.164973	
096: 0.351314	1.026697	3.463116	0.384609	0.065394	0.007951	0.269932	0.166539	
097: 0.417698	1.046124	3.475578	0.365379	0.062124	0.007554	0.255395	0.166728	
098: 0.411300	1.037570	3.479924	0.347110	0.059018	0.007176	0.233299	0.170627	
099: 0.372456	1.009531	3.466883	0.355804	0.056067	0.006817	0.241546	0.159117	
100: 0.369050	1.004997	3.464355	0.338014	0.054032	0.006476	0.251899	0.163297	
101: 0.314885	1.012833	3.447358	0.341560	0.062928	0.006153	0.257253	0.159282	
102: 0.324727	1.002909	3.429398	0.324482	0.061687	0.005845	0.306811	0.144926	
103: 0.405590	1.030967	3.443676	0.308258	0.058897	0.005817	0.280281	0.148560	
104: 0.417396	1.019539	3.451152	0.335151	0.068628	0.005527	0.313910	0.155237	
105: 0.410598	1.014794	3.445709	0.477864	0.073359	0.005250	0.287048	0.163309	
106: 0.395624	1.014088	3.447282	0.453971	0.074232	0.004988	0.280439	0.160768	
107: 0.431937	1.036136	3.452510	0.431272	0.079705	0.004738	0.269962	0.164737	
108: 0.355694	1.038541	3.448956	0.409709	0.075720	0.004501	0.277225	0.167426	
109: 0.324154	1.020657	3.456797	0.389223	0.085649	0.004402	0.274721	0.162562	
110: 0.378289	1.016658	3.445335	0.369762	0.081366	0.004182	0.259090	0.156495	
111: 0.357624	1.019487	3.449664	0.351274	0.087740	0.003973	0.266794	0.155543	
112: 0.365122	1.009260	3.449891	0.333710	0.083353	0.003774	0.281518	0.153479	
113: 0.362891	1.020479	3.454418	0.326131	0.079185	0.003586	0.283064	0.159130	
114: 0.387399	1.024657	3.458002	0.309825	0.082104	0.003406	0.307998	0.150562	
115: 0.400725	0.997315	3.450837	0.294334	0.089698	0.003660	0.273075	0.163230	
116: 0.359051	1.018869	3.456884	0.324268	0.085213	0.003807	0.262052	0.170593	
117: 0.345967	1.030213	3.459465	0.308055	0.086853	0.003617	0.270861	0.170705	
118: 0.388528	1.020935	3.458283	0.292652	0.082510	0.004007	0.308748	0.159113	
119: 0.343056	1.025998	3.457990	0.321450	0.078385	0.004811	0.249586	0.162135	
120: 0.377992	1.017729	3.462410	0.338479	0.074466	0.005570	0.266309	0.150221	
121: 0.389591	1.049514	3.454214	0.339401	0.070742	0.005292	0.287593	0.151085	
122: 0.380021	1.015145	3.453369	0.348022	0.067205	0.005027	0.272911	0.156560	
123: 0.421669	1.026486	3.449914	0.330621	0.078696	0.005113	0.276544	0.156568	
124: 0.418823	1.056433	3.453089	0.382311	0.074761	0.005682	0.288317	0.155430	
125: 0.413740	1.051391	3.453901	0.373165	0.071956	0.005967	0.298985	0.155828	
126: 0.356224	1.045800	3.442607	0.416945	0.079029	0.006046	0.305526	0.150428	
127: 0.383846	1.015327	3.438989	0.396098	0.094404	0.005916	0.327998	0.151626	
128: 0.320842	1.024036	3.447935	0.376293	0.089684	0.008068	0.312531	0.151390	
129: 0.374186	1.038683	3.456980	0.369015	0.085200	0.007664	0.290887	0.154846	
130: 0.444962	1.053226	3.454937	0.361613	0.080940	0.007281	0.298090	0.151085	
131: 0.422442	1.016042	3.449083	0.343532	0.082819	0.006917	0.332667	0.149319	
132: 0.321971	0.997057	3.435174	0.326356	0.091286	0.006571	0.298869	0.152178	
133: 0.344825	1.027585	3.438345	0.310038	0.086721	0.006242	0.315581	0.161261	
134: 0.386126	1.022497	3.456403	0.294536	0.082385	0.005930	0.260784	0.166601	
135: 0.325790	1.039720	3.442804	0.279809	0.078266	0.005634	0.269592	0.164849	
136: 0.329346	1.019273	3.443558	0.265819	0.074353	0.005352	0.243334	0.159139	
137: 0.381538	1.025959	3.447135	0.309032	0.070635	0.005085	0.262371	0.161163	
138: 0.400204	1.020687	3.453610	0.301289	0.067103	0.004830	0.321012	0.150578	
139: 0.443259	1.017864	3.467746	0.306217	0.063935	0.005250	0.337075	0.149774	
140: 0.441060	1.026052	3.480852	0.307721	0.075377	0.004987	0.275676	0.170694	
141: 0.400911	0.982982	3.490884	0.309071	0.071608	0.006213	0.293538	0.163674	
142: 0.472783	0.979880	3.496205	0.308808	0.084920	0.005903	0.261640	0.171708	
143: 0.418301	1.019483	3.501082	0.386744	0.081920	0.006103	0.251125	0.169680	
144: 0.469328	1.026690	3.509949	0.367407	0.077824	0.005798	0.253426	0.171793	
145: 0.444976	1.028270	3.496935	0.349037	0.073933	0.005508	0.243302	0.169387	
146: 0.461145	1.038691	3.501162	0.343972	0.076094	0.005233	0.271529	0.164645	
147: 0.374909	1.009371	3.493301	0.326773	0.072290	0.004971	0.245298	0.163398	
148: 0.378493	1.015805	3.484517	0.310434	0.068675	0.004723	0.258421	0.164080	
149: 0.360699	0.999846	3.478022	0.294913	0.077053	0.004487	0.276480	0.168147	
150: 0.390610	1.014307	3.484025	0.280473	0.073201	0.004262	0.285711	0.168714	
151: 0.367679	1.026221	3.473050	0.266449	0.069541	0.004049	0.248476	0.181861	
152: 0.397140	1.029101	3.478783	0.222214	0.069635	0.002677	0.271004	0.169889	
153: 0.368066	1.036516	3.481995	0.264028	0.058751	0.001950	0.273242	0.174414	
154: 0.465145	1.045522	3.486323	0.255823	0.067329	0.001953	0.265100	0.171632	
155: 0.400440	1.014720	3.482863	0.260138	0.056026	0.001759	0.264278	0.166410	
156: 0.368532	1.042254	3.484664	0.225428	0.071833	0.001991	0.266711	0.174532	
157: 0.387152	1.003944	3.488067	0.206466	0.063711	0.002608	0.257258	0.182580	
158: 0.430197	1.043659	3.485704	0.240910	0.054424	0.002039	0.259490	0.171427	
159: 0.365090	1.054743	3.490922	0.228702	0.056757	0.001745	0.254162	0.176943	
160: 0.421273	1.023322	3.489792	0.323000	0.072370	0.001659	0.261857	0.174089	
161: 0.393415	1.022011	3.492367	0.340264	0.069142	0.001971	0.258549	0.172431	
162: 0.426993	1.053552	3.478907	0.289739	0.057257	0.002181	0.284755	0.163920	
163: 0.427543	1.028926	3.472490	0.305621	0.052681	0.001632	0.310487	0.167682	
164: 0.427665	1.027284	3.473954	0.262956	0.049013	0.002021	0.254470	0.170121	
165: 0.467677	1.039030	3.487377	0.343739	0.052843	0.002042	0.253352	0.169409	
166: 0.462835	1.060103	3.483973	0.400023	0.044313	0.002209	0.234457	0.183321	
167: 0.447243	1.068388	3.490144	0.419106	0.055390	0.002571	0.234835	0.174304	
168: 0.492949	1.058172	3.501123	0.308796	0.055318	0.002355	0.253544	0.172427	
169: 0.399486	1.061310	3.493500	0.255754	0.069102	0.001530	0.262140	0.184781	
170: 0.436574	1.004502	3.492637	0.264667	0.074579	0.001318	0.248730	0.170029	
171: 0.365018	1.006221	3.488434	0.252857	0.079280	0.001479	0.259315	0.165050	
172: 0.382561	1.057967	3.485895	0.272241	0.062204	0.001263	0.266398	0.170159	
173: 0.403797	1.036741	3.482973	0.260609	0.073790	0.001964	0.260382	0.166111	
174: 0.395593	1.026019	3.482193	0.198184	0.066713	0.002079	0.261102	0.172506	
175: 0.410202	1.036114	3.471305	0.249934	0.066157	0.002672	0.283300	0.165790	
176: 0.377541	1.050386	3.471764	0.254161	0.061054	0.002031	0.278539	0.177810	
177: 0.372875	1.053343	3.480263	0.271767	0.072245	0.002221	0.270017	0.168271	
178: 0.373462	1.051080	3.479481	0.269955	0.076189	0.002498	0.279873	0.162004	
179: 0.412010	1.026165	3.479738	0.302120	0.096538	0.002074	0.351960	0.153966	
180: 0.421617	1.030873	3.484757	0.197390	0.086831	0.002048	0.322540	0.166935	
181: 0.421253	0.997796	3.474265	0.216973	0.073438	0.002149	0.274522	0.166066	
182: 0.357995	1.008038	3.474191	0.264678	0.098510	0.001867	0.265244	0.171148	
183: 0.390788	1.027715	3.470451	0.294650	0.080677	0.001656	0.299549	0.155638	
184: 0.392367	1.002954	3.462997	0.312997	0.069337	0.001598	0.276307	0.161050	
185: 0.343216	1.027116	3.456760	0.314436	0.063446	0.001634	0.263298	0.168647	
186: 0.361703	1.024870	3.461698	0.303574	0.064537	0.001928	0.254199	0.164297	
187: 0.377731	0.999045	3.466876	0.326866	0.067669	0.002260	0.281548	0.165060	
188: 0.347327	1.040311	3.457392	0.323780	0.071513	0.002312	0.282035	0.168284	
189: 0.414192	1.033745	3.459245	0.330039	0.068863	0.002409	0.302995	0.166624	
190: 0.411818	1.024919	3.462331	0.237461	0.066700	0.002356	0.262629	0.167890	
191: 0.344862	1.038877	3.459019	0.227031	0.064103	0.001887	0.258364	0.179816	
192: 0.382866	1.036016	3.455064	0.240624	0.061459	0.002290	0.245410	0.177007	
193: 0.364820	1.044668	3.455712	0.266510	0.068111	0.002113	0.270023	0.160282	
194: 0.372897	1.025483	3.451500	0.268377	0.063991	0.002376	0.263792	0.170949	
195: 0.315461	1.026722	3.456995	0.254691	0.052972	0.002210	0.253463	0.175961	
196: 0.317282	1.019161	3.461605	0.283482	0.079424	0.001898	0.289975	0.174459	
197: 0.289682	1.041829	3.462079	0.294732	0.055980	0.001861	0.253109	0.176786	
198: 0.416667	1.027809	3.458068	0.367036	0.066937	0.002469	0.256698	0.162318	
199: 0.345168	1.000516	3.458243	0.307555	0.067139	0.002524	0.252596	0.166990	
200: 0.328714	1.035042	3.453722	0.243462	0.063952	0.003492	0.259109	0.174261	
201: 0.319099	1.031143	3.456230	0.234509	0.068660	0.003732	0.265291	0.173199	
202: 0.334101	1.031064	3.454350	0.235425	0.064881	0.003758	0.261339	0.174606	
203: 0.353989	1.030670	3.454721	0.256021	0.062963	0.004048	0.264077	0.171658	
204: 0.367774	1.025031	3.455621	0.266730	0.064202	0.003743	0.270214	0.168552	
205: 0.370180	1.027266	3.454709	0.267984	0.066295	0.003658	0.276157	0.167079	
206: 0.373118	1.029991	3.455727	0.269744	0.066718	0.003513	0.281675	0.167491	
207: 0.367878	1.027882	3.455140	0.273647	0.066907	0.003397	0.278675	0.168459	
208: 0.367217	1.026033	3.455425	0.272699	0.067363	0.003309	0.277642	0.168485	
209: 0.368553	1.022693	3.455138	0.277870	0.068415	0.003390	0.278226	0.166999	
210: 0.369842	1.020987	3.454925	0.276651	0.068055	0.003399	0.279101	0.166483	
211: 0.369110	1.022186	3.455704	0.278040	0.069094	0.003318	0.279660	0.165605	
212: 0.370286	1.023677	3.456335	0.275363	0.069161	0.003253	0.281665	0.164819	
213: 0.371769	1.020959	3.456496	0.274336	0.069273	0.003172	0.279719	0.165361	
214: 0.372425	1.020784	3.456284	0.273574	0.069765	0.003164	0.279619	0.165251	
215: 0.372711	1.022062	3.456736	0.272177	0.069610	0.003204	0.279107	0.165323	
216: 0.376185	1.020579	3.456932	0.276397	0.069012	0.003214	0.278494	0.165371	
217: 0.377113	1.021873	3.456541	0.278935	0.068932	0.003267	0.279781	0.164858	
218: 0.378301	1.023147	3.456046	0.279053	0.067891	0.003253	0.278943	0.165045	
219: 0.378224	1.022463	3.454772	0.278359	0.067032	0.003271	0.279281	0.165046	
220: 0.377562	1.022728	3.454422	0.275978	0.066601	0.003221	0.279228	0.165183	
221: 0.376159	1.022764	3.454151	0.272973	0.066090	0.003223	0.278739	0.164972	
222: 0.377080	1.022213	3.454494	0.272409	0.065985	0.003270	0.279291	0.164842	
223: 0.379144	1.021642	3.454567	0.274446	0.065760	0.003306	0.279737	0.164045	
224: 0.381077	1.021715	3.455114	0.275735	0.066244	0.003333	0.280843	0.163400	
225: 0.382348	1.020482	3.455936	0.275135	0.066192	0.003392	0.280674	0.163422	
226: 0.383246	1.019916	3.456544	0.277055	0.066404	0.003451	0.281028	0.163219	
227: 0.383125	1.019886	3.456919	0.278711	0.065982	0.003495	0.280633	0.163392	
228: 0.381574	1.020824	3.456626	0.279467	0.065619	0.003574	0.279989	0.163366	
229: 0.379912	1.020739	3.456676	0.280952	0.065739	0.003674	0.279529	0.163100	
230: 0.380116	1.020626	3.456639	0.280256	0.066049	0.003719	0.280503	0.162574	
231: 0.381051	1.020735	3.456963	0.278354	0.065830	0.003753	0.280202	0.162520	
232: 0.379688	1.020686	3.457251	0.278296	0.065791	0.003789	0.279691	0.162520	
233: 0.380137	1.019741	3.457580	0.279881	0.065451	0.003825	0.279402	0.162477	
234: 0.380171	1.019775	3.457790	0.280092	0.065202	0.003830	0.279173	0.162471	
235: 0.380478	1.019753	3.457819	0.280294	0.065077	0.003794	0.279755	0.162373	
236: 0.380982	1.020394	3.457834	0.280396	0.065473	0.003767	0.279792	0.162555	
237: 0.381884	1.020565	3.457808	0.281672	0.065714	0.003769	0.279938	0.162517	
238: 0.381361	1.020938	3.457889	0.282102	0.065929	0.003763	0.280328	0.162720	
239: 0.381478	1.021764	3.457994	0.282571	0.065843	0.003752	0.280009	0.162948	
240: 0.381213	1.021277	3.458138	0.283142	0.065754	0.003718	0.279543	0.163134	
241: 0.381952	1.020557	3.458207	0.285303	0.066074	0.003710	0.279129	0.163234	
242: 0.380891	1.020007	3.458098	0.286159	0.066468	0.003713	0.278844	0.163317	
243: 0.379518	1.020469	3.457882	0.286517	0.066668	0.003736	0.278716	0.163287	
244: 0.377838	1.020412	3.457635	0.285375	0.066949	0.003751	0.278881	0.163322	
245: 0.377000	1.020204	3.457419	0.285480	0.066747	0.003762	0.278915	0.163472	
246: 0.376890	1.020020	3.457439	0.285971	0.066694	0.003783	0.280463	0.163143	
247: 0.375931	1.019753	3.457497	0.285804	0.066687	0.003775	0.280357	0.163144	
248: 0.375421	1.019951	3.457390	0.285385	0.066450	0.003772	0.280628	0.163058	
249: 0.374863	1.020044	3.457465	0.284752	0.066307	0.003772	0.280709	0.163202	
250: 0.375313	1.020536	3.457393	0.285349	0.066477	0.003777	0.281011	0.162975	
251: 0.375938	1.021210	3.457398	0.285829	0.066736	0.003764	0.281660	0.163013	
252: 0.375813	1.021767	3.457384	0.287173	0.066605	0.003771	0.281597	0.163134	
253: 0.375657	1.022002	3.457429	0.287476	0.066526	0.003781	0.281397	0.163153	
254: 0.375799	1.022586	3.457513	0.287707	0.066601	0.003795	0.281072	0.163198	
255: 0.375423	1.022954	3.457689	0.287546	0.066657	0.003824	0.281029	0.163208	
256: 0.375613	1.022827	3.457813	0.288393	0.066510	0.003856	0.280702	0.163120	
257: 0.375822	1.022365	3.457969	0.288615	0.066314	0.003852	0.280166	0.163195	
258: 0.375466	1.022550	3.457675	0.289165	0.066443	0.003844	0.280533	0.163017	
259: 0.375461	1.022287	3.457472	0.289334	0.066387	0.003831	0.280216	0.163054	
260: 0.375378	1.022509	3.457546	0.290156	0.066363	0.003825	0.280133	0.163098	
261: 0.375407	1.022578	3.457752	0.289820	0.066299	0.003826	0.279830	0.163026	
262: 0.375543	1.022926	3.457795	0.289900	0.066486	0.003818	0.280718	0.162964	
263: 0.375804	1.023484	3.457894	0.290485	0.066402	0.003836	0.280962	0.162946	
264: 0.375860	1.023539	3.458118	0.290967	0.066133	0.003847	0.280905	0.163013	
265: 0.376563	1.023619	3.458420	0.291428	0.066143	0.003856	0.281034	0.162961	
266: 0.377384	1.023989	3.458642	0.292530	0.065980	0.003875	0.281063	0.162863	
267: 0.377761	1.024101	3.458815	0.294148	0.066015	0.003880	0.280639	0.162903	
268: 0.377903	1.023855	3.458787	0.294547	0.065874	0.003864	0.280360	0.162978	
269: 0.379029	1.023430	3.458756	0.294431	0.065885	0.003862	0.280031	0.162978	
270: 0.379729	1.023409	3.458557	0.294965	0.065993	0.003862	0.280154	0.162802	
271: 0.380210	1.023354	3.458463	0.295315	0.065938	0.003865	0.280298	0.162729	
272: 0.380166	1.022950	3.458415	0.295073	0.066031	0.003868	0.280313	0.162711	
273: 0.380425	1.022950	3.458369	0.294905	0.066349	0.003876	0.281364	0.162488	
274: 0.379902	1.023022	3.458436	0.294147	0.066405	0.003880	0.282065	0.162296	
275: 0.379803	1.023001	3.458404	0.293983	0.066479	0.003869	0.281925	0.162283	
276: 0.379326	1.023090	3.458553	0.294245	0.066625	0.003867	0.281854	0.162391	
277: 0.379421	1.023343	3.458808	0.293743	0.066545	0.003863	0.281581	0.162596	
278: 0.379156	1.023340	3.458856	0.293361	0.066485	0.003850	0.282014	0.162671	
279: 0.378797	1.023208	3.458897	0.293938	0.066166	0.003836	0.282052	0.162806	
280: 0.379100	1.023701	3.459084	0.293664	0.066058	0.003830	0.282161	0.162822	
281: 0.378987	1.024108	3.459209	0.293999	0.066011	0.003827	0.282372	0.162820	
282: 0.379187	1.024384	3.459343	0.295110	0.065982	0.003827	0.282623	0.162871	
283: 0.379454	1.024351	3.459427	0.295565	0.065905	0.003827	0.282462	0.163053	
284: 0.379193	1.024135	3.459384	0.296243	0.065881	0.003814	0.282121	0.163136	
285: 0.379264	1.024092	3.459265	0.295993	0.065854	0.003809	0.282108	0.163237	
286: 0.378977	1.024261	3.459155	0.296169	0.065887	0.003816	0.281869	0.163210	
287: 0.378891	1.024588	3.459048	0.296216	0.065871	0.003827	0.282006	0.163207	
288: 0.379052	1.024604	3.458939	0.295756	0.065841	0.003836	0.281750	0.163286	
289: 0.379449	1.024531	3.458843	0.295623	0.065790	0.003841	0.281537	0.163314	
290: 0.379150	1.024613	3.458807	0.295522	0.065719	0.003828	0.281579	0.163388	
291: 0.379326	1.024863	3.458837	0.295863	0.065668	0.003827	0.281700	0.163281	
292: 0.379054	1.025011	3.458801	0.296274	0.065677	0.003828	0.281502	0.163191	
293: 0.379048	1.024859	3.458781	0.296662	0.065571	0.003821	0.281128	0.163180	
294: 0.378719	1.025010	3.458678	0.297283	0.065496	0.003811	0.280766	0.163191	
295: 0.378924	1.024769	3.458644	0.297913	0.065413	0.003804	0.280449	0.163131	
296: 0.379058	1.024644	3.458740	0.297718	0.065482	0.003803	0.280612	0.163060	
297: 0.379643	1.024733	3.458837	0.297997	0.065396	0.003809	0.280401	0.163049	
298: 0.380006	1.024771	3.458915	0.298218	0.065253	0.003812	0.279993	0.163118	
299: 0.380503	1.024788	3.458921	0.298511	0.065220	0.003797	0.279674	0.163135	
300: 0.380818	1.024821	3.459102	0.299219	0.065170	0.003795	0.279588	0.163111	
301: 0.381175	1.024771	3.459240	0.298960	0.065174	0.003798	0.279907	0.163088	
302: 0.381489	1.024921	3.459239	0.298826	0.065162	0.003804	0.279874	0.163084	
303: 0.381462	1.025100	3.459261	0.298990	0.065055	0.003809	0.279947	0.162980	
304: 0.381761	1.025273	3.459284	0.299704	0.064903	0.003812	0.280175	0.162926	
305: 0.381330	1.025034	3.459380	0.300239	0.064988	0.003830	0.280222	0.162886	
306: 0.380904	1.024849	3.459341	0.300199	0.065064	0.003847	0.280127	0.162869	
307: 0.381076	1.024947	3.459220	0.299998	0.065162	0.003846	0.280441	0.162858	
308: 0.380614	1.024825	3.459130	0.300547	0.065142	0.003849	0.280258	0.162888	
309: 0.380802	1.024800	3.459050	0.300816	0.065174	0.003860	0.280434	0.162834	
310: 0.381269	1.024628	3.459002	0.301319	0.065366	0.003858	0.281254	0.162709	
311: 0.381230	1.024732	3.459043	0.301614	0.065383	0.003849	0.281272	0.162682	
312: 0.381260	1.024707	3.458991	0.302336	0.065493	0.003847	0.281365	0.162562	
313: 0.380782	1.024426	3.458951	0.302477	0.065459	0.003845	0.281224	0.162651	
314: 0.380730	1.024339	3.458970	0.302720	0.065399	0.003842	0.281004	0.162686	
315: 0.380856	1.024396	3.459053	0.302810	0.065351	0.003836	0.280832	0.162753	
316: 0.381114	1.024377	3.459063	0.303339	0.065291	0.003829	0.280494	0.162775	
317: 0.381415	1.024445	3.459124	0.303030	0.065349	0.003825	0.280272	0.162766	
318: 0.381511	1.024458	3.459155	0.302712	0.065296	0.003813	0.280237	0.162738	
319: 0.381652	1.024507	3.459137	0.302470	0.065256	0.003809	0.280103	0.162731	
320: 0.381171	1.024498	3.459026	0.302871	0.065173	0.003799	0.279932	0.162801	
321: 0.380596	1.024525	3.458898	0.302853	0.065131	0.003802	0.279868	0.162839	
322: 0.380453	1.024546	3.458725	0.302994	0.065056	0.003803	0.279699	0.162830	
323: 0.379984	1.024416	3.458682	0.303115	0.065024	0.003810	0.279472	0.162814	
324: 0.379852	1.024497	3.458679	0.303507	0.065170	0.003802	0.279448	0.162776	
325: 0.379697	1.024720	3.458597	0.303589	0.065231	0.003801	0.279367	0.162769	
326: 0.379461	1.024565	3.458505	0.303733	0.065304	0.003791	0.279072	0.162791	
327: 0.379630	1.024605	3.458497	0.304160	0.065286	0.003793	0.278926	0.162769	
328: 0.379985	1.024822	3.458514	0.304448	0.065259	0.003791	0.278794	0.162841	
329: 0.380302	1.024914	3.458554	0.304330	0.065300	0.003794	0.278598	0.162906	
330: 0.380026	1.025031	3.458556	0.304265	0.065263	0.003800	0.278548	0.162991	
331: 0.380061	1.025213	3.458510	0.304046	0.065257	0.003798	0.278499	0.163057	
332: 0.380097	1.024958	3.458529	0.303880	0.065188	0.003797	0.278359	0.163065	
333: 0.379732	1.024881	3.458432	0.304127	0.065158	0.003797	0.278082	0.163096	
334: 0.379506	1.024653	3.458330	0.304224	0.065125	0.003798	0.278081	0.163079	
335: 0.379396	1.024779	3.458249	0.304693	0.065077	0.003792	0.277970	0.163040	
336: 0.378923	1.024843	3.458144	0.304545	0.065105	0.003798	0.277871	0.163037	
337: 0.378597	1.025088	3.458008	0.304884	0.065167	0.003802	0.277966	0.163020	
338: 0.378670	1.025310	3.457933	0.304926	0.065269	0.003802	0.278040	0.162966	
339: 0.378354	1.025558	3.457862	0.304707	0.065216	0.003800	0.277950	0.163022	
340: 0.378241	1.025538	3.457820	0.304343	0.065184	0.003799	0.277913	0.163034	
341: 0.378212	1.025561	3.457773	0.303979	0.065237	0.003795	0.277943	0.163083	
342: 0.378031	1.025464	3.457792	0.303974	0.065217	0.003795	0.277679	0.163110	
343: 0.377583	1.025475	3.457834	0.303700	0.065190	0.003788	0.277434	0.163162	
344: 0.377880	1.025438	3.457887	0.303940	0.065200	0.003787	0.277340	0.163165	
345: 0.378004	1.025475	3.457944	0.303722	0.065109	0.003798	0.277223	0.163083	
346: 0.377837	1.025511	3.457948	0.303774	0.065132	0.003794	0.277057	0.163036	
347: 0.377948	1.025474	3.457852	0.303700	0.065180	0.003809	0.277231	0.162955	
348: 0.377643	1.025572	3.457716	0.303535	0.065104	0.003819	0.277500	0.162988	
349: 0.377982	1.025519	3.457609	0.303912	0.065070	0.003828	0.277489	0.162961	
350: 0.377863	1.025355	3.457568	0.304264	0.065091	0.003833	0.277580	0.162953	
351: 0.377783	1.025509	3.457452	0.304330	0.065115	0.003835	0.277642	0.162952	
352: 0.377548	1.025533	3.457378	0.304861	0.065092	0.003839	0.277438	0.163028	
353: 0.377277	1.025708	3.457289	0.305230	0.065047	0.003846	0.277311	0.163076	
354: 0.377171	1.025774	3.457151	0.305287	0.064989	0.003862	0.277169	0.163051	
355: 0.377548	1.025714	3.457074	0.305546	0.064886	0.003877	0.277514	0.162982	
356: 0.377363	1.025618	3.457062	0.305239	0.064882	0.003878	0.277537	0.163027	
357: 0.377484	1.025703	3.457041	0.305154	0.064847	0.003874	0.277558	0.163067	
358: 0.377315	1.025685	3.457106	0.305037	0.064821	0.003867	0.277663	0.163018	
359: 0.377343	1.025836	3.457124	0.304984	0.064809	0.003856	0.277517	0.163079	
360: 0.377326	1.025826	3.457137	0.304952	0.064794	0.003852	0.277495	0.163071	
361: 0.377165	1.025774	3.457137	0.304485	0.064821	0.003849	0.277491	0.163127	
362: 0.377233	1.025734	3.457169	0.304358	0.064786	0.003846	0.277480	0.163096	
363: 0.377264	1.025629	3.457211	0.304475	0.064716	0.003843	0.277273	0.163096	
364: 0.377144	1.025671	3.457245	0.304507	0.064611	0.003845	0.277061	0.163113	
365: 0.377069	1.025604	3.457279	0.304290	0.064574	0.003853	0.276954	0.163151	
366: 0.377373	1.025625	3.457298	0.304187	0.064594	0.003854	0.276816	0.163144	
367: 0.377541	1.025744	3.457322	0.303936	0.064564	0.003859	0.276932	0.163114	
368: 0.377790	1.025953	3.457319	0.304126	0.064528	0.003868	0.276950	0.163121	
369: 0.377851	1.025949	3.457367	0.304525	0.064527	0.003871	0.276911	0.163118	
370: 0.377876	1.026105	3.457401	0.304702	0.064493	0.003879	0.277004	0.163099	
371: 0.377521	1.026141	3.457290	0.304845	0.064469	0.003882	0.277126	0.163031	
372: 0.377376	1.026195	3.457183	0.305038	0.064473	0.003885	0.277153	0.163056	
373: 0.377128	1.026286	3.457003	0.305196	0.064459	0.003888	0.277168	0.163112	
374: 0.376987	1.026265	3.456855	0.305345	0.064460	0.003886	0.277278	0.163070	
375: 0.376697	1.026227	3.456749	0.305335	0.064408	0.003887	0.277276	0.163065	
376: 0.376603	1.026277	3.456703	0.305183	0.064427	0.003888	0.277227	0.163064	
377: 0.376644	1.026283	3.456731	0.305187	0.064427	0.003884	0.277164	0.163058	
378: 0.376499	1.026140	3.456658	0.305366	0.064405	0.003879	0.277067	0.163098	
379: 0.376324	1.025971	3.456690	0.305579	0.064410	0.003872	0.276868	0.163113	
380: 0.375939	1.026123	3.456621	0.305583	0.064385	0.003869	0.276797	0.163150	
381: 0.375625	1.026147	3.456558	0.305839	0.064403	0.003865	0.276951	0.163124	
382: 0.375589	1.026128	3.456521	0.305869	0.064400	0.003860	0.276903	0.163123	
383: 0.375740	1.026100	3.456504	0.305885	0.064376	0.003867	0.276830	0.163096	
384: 0.375665	1.026057	3.456527	0.305705	0.064377	0.003866	0.276715	0.163090	
385: 0.375645	1.026085	3.456549	0.305761	0.064359	0.003868	0.276562	0.163114	
386: 0.375690	1.026215	3.456585	0.305651	0.064442	0.003867	0.276808	0.163043	
387: 0.375923	1.026210	3.456637	0.305452	0.064476	0.003870	0.276926	0.162997	
388: 0.376103	1.026260	3.456680	0.305547	0.064456	0.003869	0.277136	0.162939	
389: 0.376097	1.026159	3.456669	0.305568	0.064487	0.003863	0.277271	0.162909	
390: 0.376078	1.026192	3.456636	0.305682	0.064489	0.003862	0.277231	0.162868	
391: 0.376098	1.026200	3.456609	0.305754	0.064464	0.003859	0.277168	0.162841	
392: 0.376494	1.026321	3.456629	0.306089	0.064383	0.003858	0.277182	0.162887	
393: 0.376424	1.026338	3.456619	0.306699	0.064308	0.003853	0.277183	0.162915	
394: 0.376282	1.026384	3.456571	0.306657	0.064231	0.003850	0.277040	0.162947	
395: 0.376629	1.026501	3.456582	0.306577	0.064176	0.003844	0.277022	0.162946	
396: 0.376774	1.026673	3.456636	0.306700	0.064177	0.003838	0.277168	0.162907	
397: 0.376942	1.026687	3.456678	0.306983	0.064183	0.003846	0.277082	0.162882	
398: 0.377025	1.026667	3.456697	0.307171	0.064220	0.003847	0.277005	0.162878	
399: 0.377044	1.026553	3.456708	0.307476	0.064252	0.003847	0.277070	0.162865	
400: 0.377057	1.026718	3.456682	0.307692	0.064199	0.003851	0.277055	0.162849	
401: 0.377064	1.026877	3.456669	0.307631	0.064246	0.003855	0.277256	0.162820	
402: 0.376906	1.026880	3.456681	0.307795	0.064237	0.003862	0.277435	0.162761	
403: 0.377231	1.026792	3.456699	0.307706	0.064267	0.003866	0.277531	0.162717	
404: 0.377483	1.026846	3.456683	0.307488	0.064249	0.003860	0.277675	0.162686	
405: 0.377551	1.026932	3.456732	0.307556	0.064280	0.003856	0.277656	0.162706	
406: 0.377759	1.026959	3.456738	0.307692	0.064256	0.003857	0.277609	0.162723	
407: 0.377943	1.026954	3.456757	0.307667	0.064325	0.003855	0.277585	0.162721	
408: 0.377947	1.027111	3.456783	0.307652	0.064385	0.003859	0.277869	0.162734	
409: 0.377712	1.027109	3.456753	0.307449	0.064381	0.003864	0.277782	0.162763	
410: 0.377707	1.027217	3.456703	0.307284	0.064357	0.003871	0.277806	0.162778	
411: 0.377670	1.026985	3.456667	0.307440	0.064476	0.003880	0.278130	0.162726	
412: 0.377720	1.027052	3.456605	0.307241	0.064509	0.003881	0.278257	0.162706	
413: 0.377592	1.027071	3.456525	0.306714	0.064525	0.003880	0.278218	0.162723	
414: 0.377478	1.027095	3.456517	0.306692	0.064471	0.003878	0.278232	0.162708	
415: 0.377712	1.027125	3.456499	0.306896	0.064440	0.003878	0.278196	0.162691	
416: 0.377788	1.027293	3.456475	0.306832	0.064396	0.003874	0.278188	0.162729	
417: 0.377796	1.027407	3.456415	0.307144	0.064425	0.003873	0.278342	0.162709	
418: 0.377485	1.027501	3.456365	0.307187	0.064465	0.003874	0.278336	0.162736	
419: 0.377427	1.027622	3.456285	0.307343	0.064431	0.003879	0.278346	0.162703	
420: 0.377435	1.027629	3.456286	0.307432	0.064477	0.003874	0.278347	0.162639	
421: 0.377204	1.027674	3.456271	0.307387	0.064467	0.003871	0.278242	0.162632	
422: 0.377391	1.027606	3.456284	0.307559	0.064479	0.003871	0.278081	0.162611	
423: 0.377404	1.027590	3.456300	0.307525	0.064507	0.003865	0.278190	0.162570	
424: 0.377304	1.027584	3.456275	0.307510	0.064585	0.003860	0.278134	0.162575	
425: 0.377596	1.027568	3.456299	0.307453	0.064630	0.003857	0.278291	0.162602	
426: 0.377698	1.027644	3.456347	0.307439	0.064678	0.003855	0.278325	0.162596	
427: 0.377664	1.027602	3.456387	0.307460	0.064764	0.003856	0.278422	0.162549	
428: 0.377392	1.027624	3.456347	0.307379	0.064770	0.003859	0.278367	0.162559	
429: 0.377472	1.027570	3.456326	0.307314	0.064762	0.003862	0.278232	0.162566	
430: 0.377469	1.027593	3.456331	0.307179	0.064826	0.003864	0.278249	0.162544	
431: 0.377344	1.027623	3.456319	0.307033	0.064855	0.003863	0.278242	0.162522	
432: 0.377260	1.027715	3.456316	0.307052	0.064841	0.003859	0.278267	0.162538	
433: 0.377266	1.027806	3.456290	0.307009	0.064831	0.003857	0.278437	0.162480	
434: 0.377172	1.027809	3.456316	0.307243	0.064871	0.003857	0.278491	0.162429	
435: 0.377243	1.027773	3.456327	0.307494	0.064894	0.003854	0.278567	0.162403	
436: 0.377356	1.027712	3.456359	0.307766	0.064944	0.003852	0.279004	0.162325	
437: 0.377435	1.027711	3.456341	0.308198	0.064964	0.003848	0.278999	0.162335	
438: 0.377500	1.027866	3.456316	0.308440	0.064976	0.003845	0.279037	0.162364	
439: 0.377383	1.027937	3.456289	0.308536	0.064991	0.003844	0.279018	0.162358	
440: 0.377100	1.028000	3.456262	0.308449	0.064960	0.003842	0.279015	0.162369	
441: 0.376985	1.027998	3.456239	0.308554	0.064987	0.003844	0.278889	0.162357	
442: 0.376815	1.028053	3.456234	0.308614	0.064957	0.003842	0.278710	0.162372	
443: 0.376843	1.028038	3.456233	0.308731	0.065008	0.003836	0.278737	0.162344	
444: 0.376791	1.028028	3.456242	0.308702	0.065044	0.003832	0.278714	0.162363	
445: 0.376791	1.028004	3.456216	0.308863	0.065123	0.003825	0.278871	0.162350	
446: 0.376708	1.028001	3.456185	0.308992	0.065172	0.003820	0.278872	0.162369	
447: 0.376891	1.027916	3.456196	0.308832	0.065220	0.003815	0.278898	0.162369	
448: 0.376844	1.027949	3.456173	0.308432	0.065243	0.003814	0.278942	0.162380	
449: 0.376852	1.028018	3.456258	0.308332	0.065220	0.003816	0.278853	0.162415	
450: 0.376937	1.027946	3.456318	0.308229	0.065178	0.003817	0.278833	0.162426	
451: 0.377035	1.027990	3.456351	0.308393	0.065125	0.003822	0.278788	0.162425	
452: 0.377012	1.028080	3.456338	0.308340	0.065151	0.003819	0.278829	0.162398	
453: 0.376869	1.028085	3.456313	0.308262	0.065160	0.003814	0.278933	0.162347	
454: 0.376675	1.028226	3.456259	0.308203	0.065155	0.003810	0.278900	0.162331	
455: 0.376758	1.028284	3.456225	0.308237	0.065114	0.003807	0.278888	0.162329	
456: 0.376562	1.028262	3.456235	0.308503	0.065117	0.003805	0.278742	0.162355	
457: 0.376331	1.028214	3.456237	0.308770	0.065090	0.003801	0.278614	0.162386	
458: 0.376359	1.028249	3.456298	0.309034	0.065060	0.003798	0.278534	0.162432	
459: 0.376319	1.028355	3.456320	0.308990	0.065034	0.003798	0.278638	0.162437	
460: 0.376178	1.028415	3.456292	0.308800	0.065010	0.003795	0.278842	0.162425	
461: 0.375980	1.028517	3.456267	0.308718	0.064954	0.003795	0.278798	0.162457	
462: 0.376086	1.028573	3.456283	0.308752	0.064942	0.003795	0.278716	0.162464	
463: 0.376105	1.028631	3.456275	0.308526	0.064901	0.003796	0.278669	0.162496	
464: 0.376117	1.028664	3.456286	0.308444	0.064903	0.003792	0.278586	0.162523	
465: 0.376015	1.028526	3.456284	0.308194	0.064931	0.003787	0.278551	0.162543	
466: 0.376087	1.028578	3.456262	0.308167	0.064940	0.003784	0.278511	0.162530	
467: 0.375938	1.028606	3.456229	0.308025	0.064942	0.003784	0.278354	0.162520	
468: 0.376105	1.028651	3.456211	0.308114	0.064946	0.003784	0.278269	0.162536	
469: 0.376156	1.028725	3.456198	0.308408	0.064964	0.003782	0.278292	0.162523	
470: 0.376023	1.028791	3.456168	0.308475	0.064986	0.003780	0.278327	0.162503	
471: 0.375817	1.028817	3.456139	0.308647	0.065001	0.003777	0.278225	0.162527	
472: 0.375891	1.028787	3.456160	0.308756	0.064974	0.003774	0.278150	0.162560	
473: 0.375696	1.028797	3.456171	0.308584	0.064954	0.003773	0.278031	0.162583	
474: 0.375656	1.028785	3.456195	0.308466	0.064954	0.003770	0.277973	0.162624	
475: 0.375691	1.028852	3.456222	0.308388	0.065021	0.003767	0.278118	0.162604	
476: 0.375697	1.028850	3.456202	0.308750	0.065026	0.003764	0.278052	0.162600	
477: 0.375589	1.028859	3.456175	0.308778	0.064994	0.003764	0.277988	0.162590	
478: 0.375437	1.028834	3.456164	0.308711	0.065015	0.003761	0.277983	0.162587	
479: 0.375595	1.028881	3.456181	0.308659	0.065127	0.003760	0.278119	0.162585	
480: 0.375586	1.028893	3.456235	0.308508	0.065185	0.003761	0.278237	0.162604	
481: 0.375684	1.028868	3.456265	0.308338	0.065131	0.003759	0.278167	0.162614	
482: 0.375884	1.028822	3.456262	0.308404	0.065104	0.003762	0.278071	0.162644	
483: 0.375777	1.028735	3.456255	0.308641	0.065073	0.003761	0.278016	0.162649	
484: 0.375871	1.028679	3.456251	0.308924	0.065005	0.003759	0.277902	0.162680	
485: 0.375988	1.028697	3.456292	0.309214	0.064991	0.003757	0.278140	0.162655	
486: 0.376109	1.028724	3.456310	0.309192	0.065011	0.003756	0.278225	0.162627	
487: 0.376315	1.028660	3.456379	0.309204	0.065044	0.003757	0.278300	0.162598	
488: 0.376315	1.028568	3.456432	0.309146	0.065074	0.003758	0.278184	0.162599	
489: 0.376450	1.028484	3.456454	0.309282	0.065058	0.003761	0.278084	0.162596	
490: 0.376535	1.028539	3.456471	0.309306	0.065015	0.003762	0.278100	0.162598	
491: 0.376317	1.028590	3.456490	0.309190	0.065010	0.003763	0.278019	0.162642	
492: 0.376387	1.028610	3.456521	0.309156	0.065001	0.003767	0.277921	0.162681	
493: 0.376340	1.028632	3.456555	0.309063	0.064955	0.003770	0.277850	0.162719	
494: 0.376380	1.028644	3.456585	0.308814	0.064903	0.003770	0.277797	0.162723	
495: 0.376532	1.028614	3.456637	0.308922	0.064882	0.003766	0.277711	0.162731	
496: 0.376596	1.028660	3.456656	0.308824	0.064895	0.003766	0.277713	0.162727	
497: 0.376473	1.028655	3.456708	0.308917	0.064863	0.003766	0.277612	0.162761	
498: 0.376494	1.028650	3.456719	0.308897	0.064865	0.003763	0.277525	0.162765	
499: 0.376629	1.028642	3.456693	0.309118	0.064908	0.003758	0.277439	0.162785	
500: 0.376625	1.028566	3.456645	0.309168	0.064900	0.003755	0.277440	0.162779	
Calculating covariance matrix
[====|====|====|====|====|====|====|====|====|====] 0:00:00 

→ loading into symengine environment...
→ pruning branches (`if`/`else`) of saem model...
 done
→ finding duplicate expressions in saem predOnly model 0...
[====|====|====|====|====|====|====|====|====|====] 0:00:00 

→ finding duplicate expressions in saem predOnly model 1...
[====|====|====|====|====|====|====|====|====|====] 0:00:00 

→ finding duplicate expressions in saem predOnly model 2...
[====|====|====|====|====|====|====|====|====|====] 0:00:00 

→ optimizing duplicate expressions in saem predOnly model 2...
[====|====|====|====|====|====|====|====|====|====] 0:00:00 

 done
→ Calculating residuals/tables
 done
→ compress origData in nlmixr2 object, save 5952
→ compress phiM in nlmixr2 object, save 64632
→ compress parHist in nlmixr2 object, save 10616
→ compress saem0 in nlmixr2 object, save 27536
> 
> # }

 

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